金葡素治疗吸脂术后血清肿机制的初步探讨

目的 探讨金葡素治疗吸脂术后血清肿的可能机制.方法 对64例吸脂术后血清肿患者分别应用常规和金葡素治疗,然后每日采集渗出液,并对渗出液的比重、pH值、细胞类别及数量,以及总蛋白(TP)、碱性磷酸酶(ALP)、乳酸脱氢酶(LDH)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、γ-谷氨酰基转移酶(γ-GT)、腺苷脱氨酶(ADA)、载脂蛋白B(ApoB)、总胆固醇(TC)等生化指标进行分析.结果 金葡素治疗组患者治疗7 d后渗出液比重增高,淋巴细胞、间皮细胞的数量增加,TP、LDH、ADA、TC等多种生化指标均有明显升高,其中渗出液比重1.086±0.002、TP(42.1±0.32)g/L、LDH(343.2±9.1)U/L、ADA(19.2±5.14)U/L、TC(0.42±0.02)mmol/L.有核细胞计数平均为600×106/L,其中淋巴细胞占78%,间皮细胞占10%,与常规治疗组比较差异有统计学意义(P<0.05,P<0.01).结论 金葡素治疗组渗出液比重、细胞类别、数量以及多种生化指标的变化是金葡素刺激浆膜以及周围组织产生炎性反应引起的,无菌性炎性反应可能是金葡素治疗吸脂术后血清肿的机制.

Effect of staphylococcal enterotoxin C injection on post liposuction seroma

Objective To study the mechanism of treatment of post liposuction seroma with Staphylococcal enterotoxin C injection. Methods 64 cases with post liposuction seroma were treated with Staphylococcal enterotoxin C injection or routine procedures. The exudate of those patients was collected to analyze the ratio, pH value, cell species and numbers, and the value of TP, ALP, LDH, AST, ALT, γ-GT,ADA, ApoB, TC. Results The ratio, numbers of lymphocyte and mesothelial cells and TP, LDH,ADA, TC value in exudate in Staphylococcal enterotoxin C group were significantly higher than those in control group. Conclusions The effect of Staphylococcal enterrtoxin C injection on the exudate of seroma may be related to the non-inflammation reaction.