| 麻黄汤配方颗粒剂与标准汤剂的HPLC指纹图谱研究 |
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| 引用本文： | 王丽莉,刘晓秋,陈发奎. 麻黄汤配方颗粒剂与标准汤剂的HPLC指纹图谱研究[J]. 中成药, 2006, 28(6): 784-787 |
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| 作者姓名： | 王丽莉 刘晓秋 陈发奎 |
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| 作者单位： | 沈阳药科大学,辽宁,沈阳,110016 |
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| 摘 要： | 目的:建立麻黄汤(麻黄、甘草、桂枝和苦杏仁)配方颗粒剂的HPLC指纹图谱,通过与传统汤剂进行比较,为麻黄汤配方颗粒剂的可行性提供依据。方法:采用反相高效液相色谱法,流动相为甲醇-0.01 mol/L磷酸二氢钾水溶液(磷酸调pH=3)进行梯度洗脱。结果:确定了26个共有峰,得到了以甘草次酸为参照的相对峰面积值。结论:两者主要指标成分的相对含量差别不大,麻黄汤配方颗粒剂有其合理性。
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| 关 键 词： | HPLC 指纹图谱 麻黄汤配方颗粒剂 麻黄汤标准汤剂 |
| 文章编号： | 1001-1528（2006）06-0784-03 |
| 收稿时间： | 2005-04-20 |
| 修稿时间： | 2005-04-20 |
HPLC fingerprints of Mahuangtang dispensing granule and standard decoction |
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| WANG Li-li,LIU Xiao-qiu,CHEN Fa-kui. HPLC fingerprints of Mahuangtang dispensing granule and standard decoction[J]. Chinese Traditional Patent Medicine, 2006, 28(6): 784-787 |
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| Authors: | WANG Li-li LIU Xiao-qiu CHEN Fa-kui |
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| Affiliation: | Shenyang Pharmaceutical University, Shenyang 110016, China |
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| Abstract: | AIM: To study the difference in main chemical composition and content between Mahuangtang Herb Ephedrae;Radix et Rhizoma Gly Cyrrhizae;Ramulus Cinnamoni;Semen Armeniacea Amarum;dispensing granule and its standard decoction. METHODS: RP-HPLC was used to create fingerprinits with MeOH-0.01 mol/L KH_2PO_4(H_3PO_4 adjusted pH=3),a gradient eluting agent. RESULTS: 26 co-possessing peaks were indicated,the retention time and relative peak area were obtained. CONCLUSION: The difference between Mahuangtang dispensing granule and standard decoction is not obvious,the former is rational. |
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| Keywords: | HPLC fingerprints Mahuangtang dispensing granule Mahuangtang standard decoction |
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