| 鳖甲煎丸抗肝纤维化作用机制的研究进展 |
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| 引用本文： | 孙悦,刘莹,王磊,蔡嵘,董林毅.鳖甲煎丸抗肝纤维化作用机制的研究进展[J].现代药物与临床,2024,39(2):522-529. |
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| 作者姓名： | 孙悦 刘莹 王磊 蔡嵘 董林毅 |
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| 作者单位： | 天津市第五中心医院生态城医院 药剂科, 天津 300467;天津医科大学 药学院, 天津 300070 |
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| 基金项目： | 天津市教委科研计划项目（2022ZD053） |
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| 摘 要： | 肝纤维化是肝脏对于各种病因所致的慢性肝损伤而引发自身愈合修复的一种反应。目前尚无治疗肝纤维化、肝硬化的有效手段和药物。鳖甲煎丸临床上主要用于病毒性肝炎后肝纤维化和代谢相关脂肪性肝病纤维化治疗。鳖甲煎丸可调节免疫、调控相关因子、调控相关信号通路、调控细胞周期，发挥抗肝纤维化作用。总结了鳖甲煎丸抗肝纤维化作用机制的研究进展，以期为鳖甲煎丸今后的研究方向和临床应用提供参考。
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| 关 键 词： | 鳖甲煎丸 抗肝纤维化 调节免疫 信号通路 细胞周期 作用机制 |
| 收稿时间： | 2023/12/11 0:00:00 |
Research progress on mechanism of Biejia Decoction Pills against hepatic fibrosis |
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| SUN Yue,LIU Ying,WANG Lei,CAI Rong,DONG Linyi.Research progress on mechanism of Biejia Decoction Pills against hepatic fibrosis[J].Drugs & Clinic,2024,39(2):522-529. |
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| Authors: | SUN Yue LIU Ying WANG Lei CAI Rong DONG Linyi |
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| Institution: | Department of Pharmacy, The Eco-city Hospital of Tianjin Fifth Central Hospital, Tianjin 300467, China; School of Pharmacy, Tianjin Medical University, Tianjin 300070, China |
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| Abstract: | Liver fibrosis is a response of the liver to chronic liver injury caused by various etiologies, leading to self-healing repair. At present, there are no effective methods or drugs for treating liver fibrosis and cirrhosis. Biejia Decoction Pills are mainly used in clinical practice for treatment of post viral hepatitis liver fibrosis and metabolic related fatty liver disease fibrosis. Biejia Decoction Pills can exert its anti-liver fibrosis effect by regulating immunity, related factors, related signaling pathways, and cell cycle. This article summarizes the research progress on mechanism of anti-liver fibrosis effect of Biejia Decoction Pills, in order to provide reference for further in-depth research and clinical applications of Biejia Decoction Pills in the future. |
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| Keywords: | Biejia Decoction Pills anti-hepatic fibrosis regulate immunity signaling pathway cell cycle mechanism |
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