原发性闭角型青光眼发病机制的研究进展

原发性闭角型青光眼(PACG)是导致失明的常见原因，房角关闭是PACG的一个基本病理过程。随着眼科设备的发展，对PACG的发病机制有了更深入的了解。除了传统的瞳孔阻滞、高褶虹膜机制，研究发现其发病原因不仅与异常眼球解剖结构相关，还与眼部动态变化因素、遗传因素和心理生理应激因素等有较为密切的关系。本文结合文献报道对PACG的发病机制和危险因素进行归纳总结，以期为临床工作提供指导作用，为青光眼的早期诊断和治疗方案的制定提供有益的理论支撑。

Research progress on the pathogenesis of primary angle-closure glaucoma

Primary angle-closure glaucoma(PACG)is a common cause of blindness, and angle closure is a fundamental pathologic process in PACG. With the development of ophthalmic equipment, the pathogenesis of PACG has been better understood. In addition to the traditional mechanisms of pupillary block and plateau iris, it has been found that its pathogenesis is not only related to abnormal ocular anatomy, but also more closely related to ocular dynamics, genetic factors, and psychophysiologic stressors. This article summarizes the pathogenesis and risk factors of PACG in conjunction with literature reports, with a view to providing guidance for clinical work and useful theoretical support for early diagnosis and treatment options for glaucoma.