| 外泌体长链非编码RNA在急性心肌梗死中的研究进展 |
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| 引用本文： | 王伯霖,闫小响.外泌体长链非编码RNA在急性心肌梗死中的研究进展[J].中国动脉硬化杂志,2024,32(1):1-8. |
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| 作者姓名： | 王伯霖 闫小响 |
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| 作者单位： | 上海交通大学医学院附属瑞金医院心脏内科,上海市 200025 |
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| 基金项目： | 国家自然科学基金重点国际合作项目(82120108003) |
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| 摘 要： | 外泌体是细胞间通讯的方式,而长链非编码RNA(lncRNA)作为外泌体内的信息载体,近年来有多项研究报道其参与了包括急性心肌梗死在内的多种心血管疾病。本文对外泌体lncRNA在急性心肌梗死领域中的相关研究进行综述,总结外泌体lncRNA发挥的调节作用,分析外泌体lncRNA作为心肌梗死标志物和治疗策略的研究现状,并通过公共数据库中的测序信息,筛选具有潜力的生物标志物。
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| 关 键 词： | 急性心肌梗死 外泌体 长链非编码RNA |
| 收稿时间： | 2023/4/24 0:00:00 |
| 修稿时间： | 2023/7/9 0:00:00 |
Research progress of exosomal long non-coding RNA in acute myocardial infarction |
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| WANG Bolin,YAN Xiaoxiang.Research progress of exosomal long non-coding RNA in acute myocardial infarction[J].Chinese Journal of Arteriosclerosis,2024,32(1):1-8. |
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| Authors: | WANG Bolin YAN Xiaoxiang |
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| Institution: | Department of Cardiovascular Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China |
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| Abstract: | Exosomes are the means of intercellular communication, and long non-coding RNAs (lncRNA), as the cargo of exosomes, are involved in regulating various physiological and pathological processes of cardiovascular system due to their rich functions. This article reviews the relevant research on extracellular lncRNA in the field of acute myocardial infarction, summarizes the regulatory role of extracellular lncRNA, analyzes the current research status of extracellular lncRNA as a biomarker and treatment strategy for myocardial infarction, and selects potential biomarkers through sequencing information in public databases. |
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| Keywords: | acute myocardial infarction exosome long non-coding RNA |
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