桂枝茯苓胶囊辅助西药治疗慢性盆腔炎临床研究

目的：观察桂枝茯苓胶囊辅助西药治疗慢性盆腔炎（CPID） 的临床疗效。方法：将90 例CPID 患者以随机数字表法分为研究组和对照组各45 例。对照组给予西药替硝唑片加盐酸左氧氟沙星胶囊治疗，研究组在对照组基础上给予桂枝茯苓胶囊辅助治疗。比较2 组临床疗效，比较2 组治疗前后中医证候积分、盆腔血流动力学［搏动指数（PI）、阻力指数（RI）、收缩期峰值血流速度（PSV）、最大血流速度（Vmax）］ 及炎症因子［白细胞介素-10（IL-10）、降钙素原（PCT）、超敏C-蛋白反应（hs-CRP）］ 水平。结果：研究组总有效率91.11%，高于对照组75.56%（P＜0.05）。治疗后，2 组各项中医证候积分均降低（P＜0.05），且研究组低于对照组（P＜0.05）。治疗后，2 组盆腔PI、RI 水平均降低（P＜0.05），且研究组低于对照组（P＜0.05），2 组盆腔PSV、Vmax 水平均升高（P＜0.05），且研究组高于对照组（P＜0.05）。治疗后，2 组血清IL-10 水平均升高（P＜0.05），且研究组高于对照组（P＜0.05），2 组血清PCT、hs-CRP 水平均降低（P＜0.05），且研究组低于对照组（P＜0.05）。结论：针对CPID 患者临床给予桂枝茯苓胶囊辅助西药治疗，可进一步提升疗效，缓解患者临床症状，改善盆腔血流动力学，减轻炎症反应。

Clinical Study on Guizhi Fuling Capsules Assisting Western Medicine for ChronicPelvic Inflammatory Disease

Abstract： Objective： To observe the clinical effect of Guizhi Fuling Capsules assisting westernmedicine on chronic pelvic inflammatory disease (CPID). Methods： A total of 90 cases of CPID patientswere divided into the study group and the control group according to the random number table method，with 45 cases in each group. The control group was treated with Tinidazole Tablets and LevofloxacinHydrochloride Capsules，and the study group was additionally treated with Guizhi Fuling Capsules based onthe treatment of the control group. Clinical effects were compared between the two groups. TraditionalChinese medicine (TCM) syndrome scores， pelvic hemodynamics [pulsatile index (PI)， resistance index(RI)， peak systolic blood flow velocity (PSV)， and maximum blood flow velocity (Vmax)]， and levels ofinflammatory factors [interleukin- 10 (IL-10)，procalcitonin (PCT)，and hypersensitive C-protein response(hs-CRP)] were compared between the two groups before and after treatment. Results：The total effectiverate was 91.11% in the study group， higher than that of 75.56% in the control group (P＜0.05). Aftertreatment，each TCM syndrome score in the two groups was decreased when compared with that before treatment (P＜0.05)， and the scores in the study group were lower than those in the control group (P＜0.05). After treatment， the levels of pelvic PI and RI in the two groups were decreased when comparedwith those before treatment (P＜0.05)， and the levels in the study group were lower than those in thecontrol group (P＜0.05)； the levels of pelvic PSV and Vmax in the two groups were increased whencompared with those before treatment (P＜0.05)，and the levels in the study group were higher than thosein the control group (P＜0.05). After treatment，serum IL-10 levels in the two groups were increased whencompared with those before treatment (P＜0.05)，and the level in the study group was higher than that inthe control group (P＜0.05)； the levels of PCT and hs- CRP in serum in the two groups were decreasedwhen compared with those before treatment (P＜0.05)，and the levels in the study group were lower thanthose in the control group (P＜0.05). Conclusion： Guizhi Fuling Capsules assisting western medicine forpatients with CPID can further enhance curative effects， relieve clinical symptoms， improve pelvichemodynamics，and reduce inflammatory reactions.