鼻渊通窍颗粒联合曲尼司特治疗变应性鼻炎的临床研究

目的 探讨鼻渊通窍颗粒联合曲尼司特治疗变应性鼻炎的临床疗效。方法 选取2021年8月—2023年5月青岛市城阳区人民医院收治的150例变应性鼻炎患者，按随机数字表法分为对照组（75例）和治疗组（75例）。对照组口服曲尼司特胶囊，1粒/次，3次/d。治疗组在对照组的基础上口服鼻渊通窍颗粒，1袋/次，3次/d。两组连服药8周。观察两组患者临床疗效，比较治疗前后两组患者症状改善时间，血清水通道蛋白5（AQP5）、白细胞介素-4（IL-4）、肿瘤坏死因子-α（TNF-α）和细胞间黏附因子-1（ICAM-1）水平及生活质量（RQLQ）评分。结果 治疗后，治疗组总有效率为97.33%，明显高于对照组（86.67%，P＜0.05）。治疗后，治疗组出现的鼻塞、喷嚏、鼻痒、流涕等症状改善时间均早于对照组（P＜0.05）。治疗后，两组血清AQP5、IL-4、TNF-α、ICAM-1水平明显降低（P＜0.05），且治疗组患者这些血清因子水平明显低于对照组（P＜0.05）。治疗后，两组RQLQ评分均明显降低（P＜0.05），且治疗组评分明显低于对照组（P＜0.05）。结论 鼻渊通窍颗粒联合曲尼司特治疗治疗变应性鼻炎可明显改善症状，促进机体炎性反应减弱，患者生活质量明显提升。

Clinical study on Biyuan Tongqiao Granules combined with tranilast in treatment of allergic rhinitis

Objective To explore the clinical effect of Biyuan Tongqiao Granules combined with tranilast in treatment of allergic rhinitis. Methods A total of 150 patients with allergic rhinitis treated in Qingdao Chengyang People’s Hospital from August 2021 to May 2023 were selected and divided into control group (75 cases) and treatment group (75 cases) according to random number table method. Patients in the control group were po administered with Tranilast Capsules, 1 grains/time, three times daily. Patients in the treatment group were po administered with Biyuan Tongqiao Granules on the basis of the control group, 1 bag/time, three times daily. Patients in two groups were treated for 8 weeks. After treatment, the clinical evaluation was evaluated, the time of symptom relief, serological AQP5, IL-4, TNF-α and ICAM-1 levels, and the scores of RQLQ in two groups before and after treatment were compared. Results After treatment, the clinical effective rate of the treatment group was 97.33%, which was significantly higher than that of the control group (86.67%, P＜0.05). After treatment, the symptoms relief time of nasal congestion, sneezing, nasal itching and runny nose in the treatment group were improved earlier than those in the control group (P＜0.05). After treatment, the serum levels of AQP5, IL-4, TNF-α and ICAM-1 in two groups significantly decreased (P＜0.05), and the levels of these serum factors in the treatment group were significantly lower than those in the control group (P＜0.05). After treatment, the RQLQ score of the two groups was significantly decreased (P＜0.05), and which in the treatment group was significantly lower than that of the control group (P＜0.05). Conclusion Biyuan Tongqiao Granules combined with tranilast can significantly improve the symptoms of allergic rhinitis, promote the weakening of organic inflammatory response, and improve the life quality of patients.