华蟾素胶囊联合化疗治疗晚期卵巢癌临床研究

目的：观察华蟾素胶囊联合多西他赛注射液、卡铂注射液治疗晚期卵巢癌的临床疗效及对细胞免疫功能的影响。方法：按随机数字表法将106例晚期卵巢癌分为对照组与治疗组各53例。对照组采取多西他赛注射液、卡铂注射液治疗，治疗组在对照组基础上联合华蟾素胶囊治疗。比较2组治疗前后细胞免疫指标(T淋巴细胞亚群CD4⁺、CD8⁺、CD4⁺/CD8⁺)、卵巢癌特异性量表第4版(FACT-OV4)评分变化，分析临床疗效和不良反应发生率。结果：治疗组总有效率为98.11%，对照组为84.91%,2组比较，差异有统计学意义(P<0.05)。治疗后，2组CD4⁺、CD4⁺/CD8⁺水平均较治疗前升高(P<0.05),CD8⁺水平较治疗前降低(P<0.05)；且治疗组CD4⁺、CD4⁺/CD8⁺水平高于对照组(P<0.05),CD8⁺...

Clinical Study on Huachansu Capsules Combined with Chemotherapy for AdvancedOvarian Cancer

Abstract：Objective：To observe the clinical effect of Huachansu Capsules combined with DocetaxelInjection and Carboplatin Injection on advanced ovarian cancer and its effect on cellular immune function.Methods：A total of 106 cases of patients with advanced ovarian cancer were divided into the control groupand the treatment group according to the random number table method，with 53 cases in each group. Thecontrol group was treated with Docetaxel Injection and Carboplatin Injection，and the treatment group wasadditionally treated with Huachansu Capsules based on the treatment of the control group. The changes incellular immune indexes [T lymphocyte subsets (CD4+，CD8+，CD4+/CD8+ ) and Functional Assessment ofCancer Therapy-Ovary Cancer (FACT-OV4) scores before and after treatment were compared between the two groups；clinical effects and incidence of adverse reactions were analyzed. Results：The total effectiverate was 98.11% in the treatment group and 84.91% in the control group，the difference being significant(P＜0.05). After treatment， the levels of CD4 + and CD4 +/CD8 + in the two groups were increased whencompared with those before treatment (P＜0.05)，and CD8 + levels were decreased when compared withthose before treatment (P＜0.05)；the levels of CD4 + and CD4 +/CD8 + in the treatment group were higherthan those in the control group (P＜0.05)，CD8 + level was lower than that in the control group (P＜0.05).After treatment，the physiological status，emotional status and additional attention scores of FACT- OV4scale in the two groups were decreased when compared with those before treatment (P＜0.05)，and thescores of functional status and social status were increased when compared with those before treatment(P＜0.05)； the scores of physiological status， emotional status and additional attention in the treatmentgroup were lower than those in the control group (P＜0.05)，and the scores of functional status and socialstatus were higher than those in the control group (P＜0.05). During the treatment period，the incidence ofadverse reactions was 3.77% in the treatment group and 18.87% in the control group，the difference beingsignificant (P＜0.05). Conclusion：Huachansu Capsules combined with Docetaxel Injection and CarboplatinInjection has a better curative effect than simple chemotherapy with western medicine in the treatment ofadvanced ovarian cancer，and it can effectively improve the cellular immune function and quality of life ofpatients，with fewer adverse reactions.