超敏C反应蛋白、降钙素原联合白细胞介素-6对手足口重症患儿的诊断价值研究 |
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引用本文: | 罗丽君,徐成高,孙飞,高晓慧,毛顺峰,陆晓萍,冯俊杰. 超敏C反应蛋白、降钙素原联合白细胞介素-6对手足口重症患儿的诊断价值研究[J]. 中国现代医生, 2024, 62(5): 16-19 |
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作者姓名: | 罗丽君 徐成高 孙飞 高晓慧 毛顺峰 陆晓萍 冯俊杰 |
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作者单位: | 嘉兴市第一医院儿科,浙江嘉兴 314000;嘉兴市第一医院内分泌科,浙江嘉兴 314000 |
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基金项目: | 浙江省嘉兴市科技计划项目(2019AD32172) |
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摘 要: | 目的 探讨超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)、降钙素原(procalcitonin,PCT)联合白细胞介素-6(interleukin-6,IL-6)在手足口重症患儿中诊断价值及临床意义。方法 收集2022年1月到2022年12月在嘉兴市第一医院住院治疗的62例手足口患儿为研究对象,根据患儿感染的严重程度分为观察组(重型感染组)29例及对照组(轻型感染组)33例,通过分析对比两组一般资料、白细胞总数、中性粒细胞计数、淋巴细胞计数、血小板计数、hs-CRP、PCT、IL-6及肌酸激酶同工酶(creatine kinase isoenzyme,CK-MB)等的差异及临床应用。结果 观察组白细胞总数、中性粒细胞计数、淋巴细胞计数、hs-CRP、PCT、IL-6较对照组有升高,差异有统计学意义(P<0.05);受试者工作特征(receiver operator characteristic,ROC)曲线分析hs-CRP预测手足口重型感染敏感度为79.3%,特异性为93.9%(95%CI:0.852~0.985,P<0....
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关 键 词: | 手足口病 超敏C反应蛋白 降钙素原 白细胞介素-6 诊断价值 |
Diagnostic value of hs-CRP and PCT combined with IL-6 in children with severe hand-foot-mouth disease |
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Abstract: | Objective To investigate the diagnostic value and clinical significance of hypersensitive C-reactive protein (hs-CRP), procalcitonin (PCT) combined with interleukin-6 (IL-6) in children with severe hand-foot-mouth disease. Methods A total of 62 children hospitalized in our hospital from January 2022 to December 2022 were collected as research objects. According to the severity of infection, they were divided into observation group (severe infection group) with 29 cases and control group (mild infection group) with 33 cases.The differences of general data, total leukocyte count, neutrophil count, lymphocyte count, platelet count, hs-CRP, PCT, IL-6 and creatine kinase isoenzyme (CK-MB) between the two groups and their clinical applications were analyzed and compared. Results The total white blood cell count, neutrophil count, lymphocyte count, hs-CRP, PCT and IL-6 in the observation group were higher than those in the control group, and the difference has statistically significant. Receiver operator characteristic (ROC) curve analysis of hs-CRP predicted the sensitivity and specificity of severe infection of hand-foot-mouth disease were 79.3% and 93.9% (95%CI: 0.852–10.985, P<0.05); The sensitivity and specificity of PCT were 93.1% and 84.8% (95%CI: 0.907-1, P<0.05); The sensitivity and specificity of IL-6 were 96.6% and 87.9% (95%CI: 0.945–1, P<0.05). Conclusions In hand-foot-mouth classification, PCT and IL-6 are highly sensitive. Although hs-CRP is less sensitive than the former, its specificity is higher than the former. Therefore, the combination of hs-CRP, PCT and IL-6 has higher value for hand-foot-mouth classification. |
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