视网膜中央动脉阻塞的治疗进展

视网膜中央动脉(CRA)是视网膜神经上皮层内五层组织的血供来源。若CRA发生阻塞，可导致患眼视力骤降甚至永久性视力丧失。视网膜中央动脉阻塞(CRAO)患者的自然视力预后通常较差。虽然可用于CRAO治疗的手段多样，如眼球按摩、前房穿刺术、高压氧治疗(HBOT)以及组织型纤溶酶原激活剂(tPA)动脉内溶栓等，但尚未有基于循证医学证据的CRAO治疗指南被应用于临床。而这些治疗手段对于CRAO的疗效均存在争议或存在治疗风险。本文将对目前可应用于CRAO治疗的措施予以综述，并对其各自的安全性及有效性进行探讨。

Progress in the treatment of central retinal artery occlusion

Central retinal artery occlusion(CRAO)refers to occlusion of the central retinal artery(CRA), which acts as the primary blood supply to the inner neurosensory retina, and leads to an acute loss of vision and permanent visual disability. The natural history of visual prognosis in CRAO is generally poor. Despite a variety of treatment options have been studied, such as ocular massage, anterior chamber paracentesis, hyperbaric oxygen therapy(HBOT)and intra-arterial infusion of tissue plasminogen activator(tPA), but there is currently no evidence-based management strategies for the treatment of CRAO. Furthermore, the efficacy of all available managements is debatable and many have uncertain risks. This review will offer a summary of the currently known treatment options for CRAO and probe into their safety and efficacy on the prognosis of CRAO.