18F-FDOPA PET/CT评估放射化学治疗用于高级别脑胶质瘤效果

目的 观察以¹⁸F-L-6-氟-3,4-二羟基苯丙氨酸(¹⁸F-FDOPA)PET/CT评估放射及化学治疗(放疗及化疗)用于高级别脑胶质瘤效果的价值。方法 回顾性分析84例接受精准放疗及同步化疗的高级别脑胶质瘤患者资料，根据疗效将其分为有效组(完全缓解+部分缓解+疾病稳定，n=60)及无效组(疾病进展，n=24)。比较组间及组内治疗前后肿瘤¹⁸F-FDOPA PET/CT代谢参数，包括肿瘤代谢体积(MTV)、最大标准摄取值(SUV_max)及平均标准摄取值(SUV_mean);以Spearman相关性分析观察代谢参数与放化疗效果的相关性。结果 治疗后有效组MTV、SUV_max及SUV_mean均低于无效组(P均<0.05)。有效组治疗前、后代谢参数差异有统计学意义(P均<0.05)。高级别脑胶质瘤MTV、SUV_max、SUV_mean与放化疗效果呈负相关(r=-0.63、-0.52、-0...

18F-FDOPA PET/CT for evaluating efficacy of radiotherapy combined with chemotherapy for advanced glioma

Objective To observe the value of ¹⁸F-fluoro-dihydroxy-phenylalanine (¹⁸F-FDOPA) PET/CT for evaluating the efficacy of radiochemotherapy for advanced glioma. Methods Data of 84 patients with advanced glioma who received precision radiotherapy combined with synchronous chemotherapy were retrospectively analyzed. The patients were divided into effective group (complete remission+partial remission+stable disease, n=60) and ineffective group (progressive disease, n=24) according to the efficacy of radiochemotherapy. ¹⁸F-FDOPA PET/CT metabolic parameters of tumors, including tumor metabolic tumor volume (MTV), maximum standard uptake value (SUV_max) and mean standard uptake value (SUV_mean) were compared between groups, also before and after radiochemotherapy within groups. Spearman correlation analysis was used to observe the correlations of metabolic parameters and the efficacy of radiochemotherapy. Results After radiochemotherapy, MTV, SUV_max and SUV_mean of tumors in effective group were lower than those of tumors in ineffective group (all P<0.05). Significant differences of metabolic parameters were found before and after radiochemotherapy in effective group (all P<0.05). MTV, SUV_max and SUV_mean of advanced glioma were negatively correlated with the efficacy of radiochemotherapy (r=-0.63, -0.52, -0.50, P<0.001, P=0.007, P=0.010). Conclusion ¹⁸F-FDOPA PET/CT was helpful for evaluating the efficacy of radiochemotherapy for advanced glioma.