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血管生物力学与力学生物学研究进展
引用本文:张红萍,赵川榕,王贵学.血管生物力学与力学生物学研究进展[J].医用生物力学,2024,39(1):17-23.
作者姓名:张红萍  赵川榕  王贵学
作者单位:重庆大学 生物工程学院,生物流变科学与技术教育部重点实验室,血管植入物开发国家地方联合工程实验室;金凤实验室
基金项目:国家重点研发计划项目(2023YFB3810100),国家自然科学基金重点项目(12032007),金凤实验室(重庆)科技创新项目(jfkyjf202203001)
摘    要:血管生物力学主要探讨血管细胞如何感知力学刺激、力学如何影响疾病发生发展以及开发多种数理模型来分析力学因素对疾病的作用。近年来,血管生物力学领域的研究蓬勃发展,各科研团队从不同方向解析血管的力学生物学过程,以期深入了解血管生物力学因素影响各种血管疾病进程的调控机制,为心脑血管疾病的防治提供基于力学生物学的理论基础。本文基于国内外专家团队并结合本团队研究工作,对血管力学生物学领域近期的研究热点和新兴趋势进行总结探讨,为把握血管力学生物学领域热点和探索新的研究方向提供系统框架。

关 键 词:血管生物力学  力学生物学  计算流体动力学  血管支架  动脉瘤  有限元分析
收稿时间:2024/1/28 0:00:00
修稿时间:2024/1/30 0:00:00

Advances in Vascular Biomechanics and Mechanobiology
ZHANG Hongping,ZHAO Chuanrong,WANG Guixu.Advances in Vascular Biomechanics and Mechanobiology[J].Journal of Medical Biomechanics,2024,39(1):17-23.
Authors:ZHANG Hongping  ZHAO Chuanrong  WANG Guixu
Abstract:Vascular biomechanics mainly explores how vascular cells perceive mechanical stimuli, how mechanics affects the development of diseases, and the exploitation of various mathematical models to analyze the effects of mechanical factors on diseases. In recent years, researches in the field of vascular biomechanics are developing rapidly, and various research teams have analyzed the mechanical and biological processes of blood vessels from different directions, in order to gain a deeper understanding of the regulatory mechanisms of vascular biomechanical factors affecting the progression of various vascular diseases, and provide a theoretical basis based on the mechanobiology for the prevention and treatment of cardiovascular and cerebrovascular diseases. This article summarizes and discusses the recent research hotspots and emerging trends in the field of vascular mechanobiology based on domestic and foreign expert teams and combined with our team''s research work, thus providing a systematic framework for grasping hotspots and exploring new research directions in the field of vascular mechanobiology.
Keywords:vascular biomechanics  mechanobiology  computational fluid dynamics  intravascular stents  aneurysms  finite element analysis
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