| 原发性皮肤黏液癌2例临床病理观察 |
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| 引用本文： | 宋红杰,刘冲,曾铮,马恒辉,周航波,王海,石群立. 原发性皮肤黏液癌2例临床病理观察[J]. 诊断病理学杂志, 2011, 18(6): 443-446. DOI: 10.3969/j.issn.1007-8096.2011.06.015 |
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| 作者姓名： | 宋红杰 刘冲 曾铮 马恒辉 周航波 王海 石群立 |
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| 作者单位： | 1. 海门市人民医院病理科,江苏海门,226100
2. 南京军区南京总医院病理科,南京,210002 |
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| 摘 要： | 目的探讨原发性皮肤黏液癌的临床病理学特点及预后。方法应用光镜观察、免疫组化等方法对2例原发性皮肤黏液癌进行分析,并复习相关文献。结果皮肤原发性黏液癌生长缓慢,病程常为数年甚至数十年。组织学上,肿瘤主要位于真皮层,并常累及皮下脂肪组织,癌细胞团块呈岛状漂浮在淡染的黏蛋白湖中,周围由纤细的纤维将其分隔;癌细胞为立方形、圆形或卵圆形,胞质丰富,淡红染,细胞核圆形或卵圆形,居中,核分裂象少见。免疫组化:癌细胞CK7、ER、PR、CEA和GCDFP-15(+),CK20、CDX-2、CA125,TTF1、c-erbB-2、PSA和villin均(-),Ki-67低表达(通常<5%)。结论原发于皮肤的黏液癌罕见,组织学上与转移性黏液癌鉴别困难,须结合临床及免疫组化标记排除转移癌后方可诊断。该肿瘤恶性度低,治疗主要采用手术切除肿瘤,预后较好。
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| 关 键 词： | 皮肤 黏液癌 免疫组化 鉴别诊断 预后 |
Primary cutaneous mucinous carcinoma: a clinicopathologic study of 2 cases |
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| SONG Hong-jie,LIU Chong,ZENG Zheng,MA Heng-hui,ZHOU Hang-bo,WANG Hai,SHI Qun-li. Primary cutaneous mucinous carcinoma: a clinicopathologic study of 2 cases[J]. Chinese Journal of Diagnostic Pathology, 2011, 18(6): 443-446. DOI: 10.3969/j.issn.1007-8096.2011.06.015 |
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| Authors: | SONG Hong-jie LIU Chong ZENG Zheng MA Heng-hui ZHOU Hang-bo WANG Hai SHI Qun-li |
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| Affiliation: | SONG Hong-jie1,LIU Chong2,ZENG Zheng2,MA Heng-hui2,ZHOU Hang-bo2,WANG Hai2,SHI Qun-li2(1.Department of pathology,Haimen People's Hospital,Haimen 226100,China,2.Department of Pathology,Nanjing General Hospital of PLA,Nanjing 210002,China) |
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| Abstract: | Purpose To investigate the clinicopathological feature and immunophenotype of primary cutaneous mucinous carcinoma(PCMC).Methods Two cases of PCMC were studied by microscopic observation and immunohistochemical staining,with a review of the related literatures.Results PCMC was a slow-growing tumor,often growing few years or few decades.Histologically,the tumor located in corium,and often invaded in the fat tissue.The definitive histopathology showed small cellular nests of adenocarcinoma lying in pools of e... |
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| Keywords: | Skin Mucinous carcinoma Immunohistochemistry Differential diagnosis Prognosis |
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