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| 大肠癌中淋巴管密度和VEGF-A表达与微血管密度的关系 | |
| 引用本文： | 林梅,纪萍,马树沛,解丹,于建宪. 大肠癌中淋巴管密度和VEGF-A表达与微血管密度的关系[J]. 诊断病理学杂志, 2011, 18(6): 454-457. DOI: 10.3969/j.issn.1007-8096.2011.06.019 |
| 作者姓名： | 林梅 纪萍 马树沛 解丹 于建宪 |
| 作者单位： | 1. 青岛市市立医院中心实验室 2. 青岛市市立医院病理科 3. 青岛市市立医院内科,山东青岛,266011 |
| 基金项目： | 山东省卫生厅资助项目，青岛市科技局资助项目 |
| 摘 要： | 目的探讨大肠癌中淋巴管密度(LVD)和血管内皮生长因子-A(VEGF-A)的表达与微血管密度(MVD)的关系。方法应用抗podoplanin及抗VEGF-A单克隆抗体检测大肠癌组织及相应正常大肠组织中的LVD,并计数CD34阳性着色的大肠癌组织MVD。结果①大肠癌组织中的LVD明显高于相应的正常组织(P<0.01),LVD与淋巴管内癌栓密切相关(P<0.05)。②VEGF-A在大肠癌组织中的表达显著高于相应正常组织(P<0.01),VEGF-A的表达与MVD(P<0.05)相关但与LVD无关(P>0.05)。③大肠癌中MVD显著高于LVD(P<0.01),但两者无关。结论淋巴管的形成在大肠癌的发生、发展过程中起重要的作用;VEGF-A在大肠癌组织中可诱导微血管形成但与淋巴管的形成无关;大肠癌的MVD显著高于LVD,但两者无相关性,提示血管形成及淋巴管形成在大肠癌的发生、发展过程中可能为相互独立的过程。 |
| 关 键 词： | 淋巴管密度 微血管密度 VEGF-A 结直肠癌 |
Relationship of lymphatic vessel density and VEGF-A expression with microvessel density in colorectal cancer |
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| LIN Mei,JI Ping,MA Shu-pei,XIE Don,YU Jian-xian. Relationship of lymphatic vessel density and VEGF-A expression with microvessel density in colorectal cancer[J]. Chinese Journal of Diagnostic Pathology, 2011, 18(6): 454-457. DOI: 10.3969/j.issn.1007-8096.2011.06.019 | |
| Authors: | LIN Mei JI Ping MA Shu-pei XIE Don YU Jian-xian |
| Affiliation: | LIN Mei1,JI Ping2,MA Shu-pei3,XIE Dan2,YU Jian-xian2(1.Laboratory Medicine,2.Department of Pathology,3.Department of Internal Medicine,Qingdao Municipal Hospital,Qingdao 266011,China) |
| Abstract: | Objective To investigate the relationships of lymphatic vessel density(LVD) and the expression of vascular endothelial growth factor-A(VEGF-A) with microvessel density(MVD) in colorectal cancer.Methods Immunohistochemical staining with monoclonal antibodies against human podoplanin and VEGF-A was used to examine LVD and VEGF-A expression in 81 cases of colorectal cancer and corresponding normal tissues and CD34 positively stained MVD was also calculated in the cancer tissue samples.Results The LVD of colore... |
| Keywords: | LVD MVD VEGF-A Colorectal cancer |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |