中药冠心康对实验性家兔动脉粥样硬化模型血液流变性的影响

目的 :研究中药冠心康对血液流变性的影响 ,为探索益气通阳化痰中药冠心康在防治高粘血症中的作用机制提供理论依据。方法 :采用食饵性家兔高脂血症及动脉粥样硬化模型 ,分四组 (空白对照组、模型对照组、活血化瘀法对照组、益气通阳化痰法治疗组 )进行对比研究。实验开始时及第 12周分别测定下述指标 :( 1)血小板粘附性和血小板聚集性 ;( 2 )血液流变学主要指标 :全血粘度、血浆粘度、红细胞压积、血沉、红细胞聚集指数、红细胞变形指数。结果 :( 1)高脂组血小板粘附性和聚集性明显高于其它三组 (P <0 .0 5 ) ,化痰组与活血组之间无显著差异 (P >0 .0 5 )。 ( 2 )化痰组与活血组都具有降低血粘度的作用 (P <0 .0 5 ) ,化痰组在降低全血粘度和红细胞聚集指数方面优于活血组 (P <0 .0 5 )。结论 :中药冠心康能有效地防治高脂血症 ,在某些方面优于活血化瘀中药。

Effect of GuanXinKang to Experimental Atheroscleresis in Rabbits on Hemorrheology

Objective: To study the effect and mechanism of Chinese medcine GuangXinKang(GXK)on hemorrheology.So as to provid theoretical guide for researching the mechanism of GXK in prevention and cure of atheroscleresis.Method: The rabbit′s model is established by feeding the cholesterol contained food for 12 weeks.All rabbits are divided four groups:normal group(N group),model group(M group),control group(C guoup)and treat group(T group).At the experiment beginning and the twelfth weekend,the items as follows are measured:(1)ratio of blood viscosity(RBV),ratio of plasma viscosity(RPV),hematocrit(HCT),red blood cell aggregation index(RAI).(2)platelet aggregation function(PAgF)and platelet adhesion(PAdF).Results: (1)Before the experiment,PAgF and PAdF of each group has not sigrificant difference( P> 0.05 ),but at the experimental end,M group is higher than other three groups( P< 0.05 ).T group and C group have not significant difference( P> 0.05 ).(2)At the experimental end,RBV and RAI of C group and M group have not significant difference,but RPV and HCT of the two groups have significant difference( P> 0.05 ). Conclusion: GXK can significantly change hemorrheology and in some items it better than Chinese medicine of Huexue Method.