同型半胱氨酸与老年冠心病的相关性研究

目的探讨血浆同型半胱氨酸(Hcy)水平与老年冠心病(CHD)的发生及严重程度的相关性。方法选择30例健康老年人(对照组)和70例老年冠心病患者(CHD组),其中老年冠心病组又分为26例心肌梗死型冠心病(AMI)、24例不稳定性心绞痛型冠心病(UAP)及20例稳定性心绞痛型冠心病(SAP),分别测定其血浆Hcy水平,同时测定其血脂水平包括总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)。结果 CHD组Hcy水平明显高于对照组(P<0.01),3组间Hcy水平比较AMI>UAP>SAP(P<0.05),同时CHD组中对血浆Hcy与TG、TC、LDL-C、的相关分析结果显示,血浆Hcy与其无明显相关(P>0.05)。结论血浆Hcy水平是老年冠心病的独立危险因素之一,且升高水平与冠脉病变严重程度相关。

Study on the relationship between plasma homocysteine and coronary heart disease in elderly patients

Objective To investigate the relationship between plasma homocysteine（HCY） and elderly coronary heart disease（CHD） and its severity.Methods To determine 30 healthy elderly peoples（control group） and 70 elderly coronary heart diseases（CHD group）,CHD group were divided into 26 cases suffering from myocardial infarction（AMI）,24 cases suffering from unstable angina pectoris and 20 cases suffering from stable angina pectoris.All of the objects were determined of their plasma Hcy,triglyceride（TG）,total cholesterol（TC） and low density lipoprotein cholesterol（LDL-C）.Results The plasma Hcy levels was significantly higher in CHD group than that in control group（P〈0.01）.Hcy level in the UAP group was lower than that in the AMI group,but higher than in the SAP group（P〈0.05）.Logistic-regression analysis showed that Hcy had no significant correlation with TC,TG and LDL-C in CHD group（P〈0.05）.Conclusion Plasma level of Hcy is an independent risk factor for the occurrence of coronary heart disease,and closely related to the severity of the disease in elderly patients.