| 血红蛋白基纳米氧载体:结构特点、高铁含量控制及血循环中持久存在(英文) |
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| 引用本文： | 袁媛,章晓兰,刘昌胜,ZHAO Jian,SHENG Yan,SHAN Xiao-qian,XU Feng. 血红蛋白基纳米氧载体:结构特点、高铁含量控制及血循环中持久存在(英文)[J]. 东南大学学报(医学版), 2011, 30(1): 72-82. DOI: 10.3969/j.issn.1671-6264.2011.01.015 |
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| 作者姓名： | 袁媛 章晓兰 刘昌胜 ZHAO Jian SHENG Yan SHAN Xiao-qian XU Feng |
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| 作者单位： | 袁媛,刘昌胜,YUAN Yuan,LIU Chang-sheng(The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China;Key Laboratory for Ultrafine Materials of Ministry of Education, and Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China);章晓兰,ZHAO Jian,SHENG Yan,SHAN Xiao-qian,XU Feng,ZHANG Xiao-lan,ZHAO Jian,SHENG Yan,SHAN Xiao-qian,XU Feng(Key Laboratory for Ultrafine Materials of Ministry of Education, and Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, China) |
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| 基金项目： | National High Technology Research and Development Program of China (863 program)(2004AA-302050);Shanghai Nanotechnology Special Foundation (0452nm022) |
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| 摘 要： | Due to the continuously insufficient supply and the disadvantages associated with the donated blood,artificial blood substitute has received extensive attentions throughoutthe world in recentyears.Nano-structured hemoglobin-based oxygen carriers (NHOCs),in particular the liposome-encapsulated hemoglobin (LEH) and hemo-globin-based polymeric nanoparticles (HbPNPs),which combine the nanotechnology with the traditional cellular oxygen carriers,have shown great potential applications in blood transfusion,thrombus and cancer therapy as well.The present article firstly reports on the current status of the synthesis,properties,clinical trial and application of the LEHand HbPNPs.And then,attentions are devoted to highlight the main challenges and the proposed strategies of the NHOCs with the respect of suppression of the methemoglobin formation and prolonging the blood circulation time.These results make us confident in advancing further development of NHOCs,with the expectation of their eventual commercialization.
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| 关 键 词： | nano-structured hemoglobin-based oxygen carriers current status liposome-encapsulated hemoglo-bin hemoglobin-based polymeric nanoparticles review |
Nano-structured hemoglobin-based oxygen carriers: from properties, methemoglobin suppression to long circulation in blood |
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| YUAN Yuan,ZHANG Xiao-lan,LIU Chang-sheng,ZHAO Jian,SHENG Yan,SHAN Xiao-qian,XU Feng. Nano-structured hemoglobin-based oxygen carriers: from properties, methemoglobin suppression to long circulation in blood[J]. Journal of Southeast Univ: Medical Sci Ed, 2011, 30(1): 72-82. DOI: 10.3969/j.issn.1671-6264.2011.01.015 |
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| Authors: | YUAN Yuan ZHANG Xiao-lan LIU Chang-sheng ZHAO Jian SHENG Yan SHAN Xiao-qian XU Feng |
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| Affiliation: | 1,2,ZHAO Jian2,SHENG Yan2,SHAN Xiao-qian2,XU Feng2(1.The State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,China;2.Key Laboratory for Ultrafine Materials of Ministry of Education,and Engineering Research Center for Biomedical Materials of Ministry of Education,East China University of Science and Technology,Shanghai 200237,China) |
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| Abstract: | Due to the continuously insufficient supply and the disadvantages associated with the donated blood, artificial blood substitute has received extensive attentions throughout the world in recent years. Nano-structured hemoglobin-based oxygen carriers (NHOCs), in particular the liposome-encapsulated hemoglobin (LEH) and hemoglobin-based polymeric nanoparticles (HbPNPs), which combine the nanotechnology with the traditional cellular oxygen carriers, have shown great potential applications in blood transfusion, thrombus and cancer therapy as well. The present article firstly reports on the current status of the synthesis, properties, clinical trial and application of the LEH and HbPNPs. And then, attentions are devoted to highlight the main challenges and the proposed strategies of the NHOCs with the respect of suppression of the methemoglobin formation and prolonging the blood circulation time. These results make us confident in advancing further development of NHOCs, with the expectation of their eventual commercialization. |
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| Keywords: | nano-structured hemoglobin-based oxygen carriers current status liposome-encapsulated hemoglobin hemoglobin-based polymeric nanoparticles review |
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