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| 磁性纳米纤维复合材料原位诱导体内成骨的研究 | |
| 引用本文： | 许振,孟洁,张宇,常晓,边焱焱,孔桦,顾宁,许海燕.磁性纳米纤维复合材料原位诱导体内成骨的研究[J].东南大学学报(医学版),2011,30(1):1-6. |
| 作者姓名： | 许振 孟洁 张宇 常晓 边焱焱 孔桦 顾宁 许海燕 |
| 作者单位： | 1. 中国医学科学院,基础医学研究所,中国协和医科大学,生物医学工程系,北京,100005 2. 东南大学,生物科学与医学工程学院,江苏,南京,210096 3. 北京协和医院,骨科,北京,100073 |
| 基金项目： | National Natural Science Foundation of China(30970710);Beijing Municipal Natural Science Foundation(2102046) |
| 摘 要： | 目的:研究一种新型顺磁性的纳米纤维复合支架γ-Fe2O3/nHAP/PDLLA在弱磁场下体内诱导新骨形成的功效.方法:纳米纤维复合材料支架通过电纺丝方法制成,支架内部的微观结构用扫描电镜(SEM)进行表征.将支架植入兔横突根部骨缺损处并在12周后处死动物,应用组织学方法研究支架在动物体内原位诱导新骨形成和胶原蛋白沉积的... |
| 关 键 词： | 纳米纤维支架 γ-Fe2O3/nHAP/PDLLA复合材料 Ⅰ型胶原 骨再生 兔 |
Enhancement of a magnetic nanofibrous composite scaffold for bone regeneration |
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| XU Zhen,MENG Jie,ZHANG Yu,CHANG Xiao,BIAN Yan-yan,KONG Hua,GU Ning,XU Hai-yan.Enhancement of a magnetic nanofibrous composite scaffold for bone regeneration[J].Journal of Southeast Univ: Medical Sci Ed,2011,30(1):1-6. | |
| Authors: | XU Zhen MENG Jie ZHANG Yu CHANG Xiao BIAN Yan-yan KONG Hua GU Ning XU Hai-yan |
| Institution: | 1(1.Department of Biomedical Engineering,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing100005,China;2.School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China;3.Department of Orthopaedics Surgery,Peking Union Medical Hospital,Beijing 100073,China) |
| Abstract: | Objective: To investigate the function of inducing bone regeneration of a novel paramagnetic nanofibrous composite scaffold of γ-Fe2O3/nHAP/PDLLA in vivo under a weak applied magnetic field. Methods: The scaffold was fabricated with the composite by electrospinning technique. The microstructure of the scaffold was characterized by scanning electron microscopy. The scaffold was implanted in defects at the root segment of the lumbar transverse process on a rabbit model. Bone tissue samples were collected after 12 weeks of implant surgery. New bone formation in the defects was assessed using histological analysis in reference to a control nanofibrous composite of nHAP/PDLLA. Deposition of type Ⅰ collagen fibers were examined by Sirius red staining. Results: There was new bone formation observed in the scaffold. Type Ⅰ collagen was deposited abundantly on the scaffold. Together all, the bone regeneration was enhanced obviously in comparison with that induced by control scaffold of nHAP/PDLLA. Conclusion: The scaffold of γ-Fe2O3/nHAP/PDLLA enhanced osteogenesis under a weak static magnetic field, and exhibited promising potential for use in bone repair. |
| Keywords: | nanofibrous scaffold composite of γ-Fe2O3/nHAP/PDLLA type Ⅰ collagen bone regeneration rabbits |
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