| 抗神经生长因子抗体对变应性鼻炎大鼠鼻黏膜炎症的影响 |
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| 引用本文： | 罗一鸣,黄志纯,孙宝宾,陶峰. 抗神经生长因子抗体对变应性鼻炎大鼠鼻黏膜炎症的影响[J]. 东南大学学报(医学版), 2011, 30(3): 495-499. DOI: 10.3969/j.issn.1671-6264.2011.03.023 |
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| 作者姓名： | 罗一鸣 黄志纯 孙宝宾 陶峰 |
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| 作者单位： | 1. 东南大学,医学院,江苏,南京,210009
2. 东南大学附属中大医院,耳鼻咽喉科,江苏,南京,210009 |
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| 摘 要： | 目的:探讨鼻腔滴入抗神经生长因子抗体对变应性鼻炎大鼠鼻黏膜炎症的影响。方法:将40只SD大鼠随机分成实验组30只和对照组(A组)10只,实验组大鼠采用卵清蛋白致敏和激发制成变应性鼻炎大鼠模型,再将大鼠模型随机分为变应性鼻炎组(B组)、抗神经生长因子抗体处理组(C组)、布地奈德治疗组(D组)3组。各组鼻腔给予卵清蛋白激发,每日1次,共7次。C组在激发之前鼻腔给予抗神经生长因子抗体处理,D组在激发之前鼻腔给予布地奈德处理,B组在激发之前鼻腔内以生理盐水代替药物处理。在末次激发之后,通过行为学观察、鼻黏膜病理切片、鼻腔灌洗液和血清中IL-4的含量等指标来评价抗神经生长因子抗体对变应性鼻炎大鼠鼻黏膜炎症的影响。结果:C组和D组行为学评分低于B组,A组无特殊反应;B组鼻黏膜呈典型变应性鼻炎病理改变,可见较多嗜酸粒细胞浸润,鼻腔灌洗液上清液和血清中IL-4的含量均高于A组(P<0.05);C组和D组动物的鼻黏膜病理性改变减轻,嗜酸粒细胞浸润减少,鼻腔灌洗液上清液和血清中IL-4的含量较B组下降明显(P<0.05)。结论:鼻腔滴入抗神经生长因子抗体可有效缓解变应性鼻炎大鼠鼻腔局部症状,减轻鼻黏膜病理性改变,并减少大鼠IL-4的合成与分泌。
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| 关 键 词： | 变应性鼻炎 抗神经生长因子抗体 白细胞介素-4 大鼠 |
Effects of anti-NGF antibody on the nasal mucosa inflammation of experimental allergic rhinitis animal |
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| LUO Yi-ming,HUANG Zhi-chun,SUN Bao-bin,TAO Feng. Effects of anti-NGF antibody on the nasal mucosa inflammation of experimental allergic rhinitis animal[J]. Journal of Southeast Univ: Medical Sci Ed, 2011, 30(3): 495-499. DOI: 10.3969/j.issn.1671-6264.2011.03.023 |
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| Authors: | LUO Yi-ming HUANG Zhi-chun SUN Bao-bin TAO Feng |
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| Affiliation: | LUO Yi-ming1,HUANG Zhi-chun 2,SUN Bao-bin2,TAO Feng2(1.Medical School,Southeast University,Nanjing 210009,China,2.Department of Otolaryngology,Zhongda Hospital,China) |
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| Abstract: | Objective: To investigate the effects of anti-NGF antibody on the nasal mucosa inflammation of rat models with allergic rhinitis.Methods: Forty SD rats were randomly divided into 2 groups:the control group(group A) and the experimental group.First of all,those rats in experimental group were sensitized by using ovalbumin(OVA) intraperitoneal immunization and nasal antigen challenge.Group A was treated as a negative control group sensitized and challenged by normal saline instead of OVA.Then,the experimental... |
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| Keywords: | allergic rhinitis anti-NGF antibody IL-4 rats |
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