| 核素131I联合低频超声微泡治疗兔VX2肝肿瘤的实验研究 |
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| 引用本文： | 徐国厚,杜明华,钟英,戚宁. 核素131I联合低频超声微泡治疗兔VX2肝肿瘤的实验研究[J]. 东南大学学报(医学版), 2011, 30(3): 486-490. DOI: 10.3969/j.issn.1671-6264.2011.03.021 |
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| 作者姓名： | 徐国厚 杜明华 钟英 戚宁 |
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| 作者单位： | 东南大学附属中大医院,核医学科,江苏,南京,210009 |
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| 基金项目： | 东南大学国家自然科学基金预研项目 |
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| 摘 要： | 目的:探讨核素131I联合低频超声微泡治疗接种于新西兰大白兔肝左叶VX2肝肿瘤的疗效。方法:将成功建立肿瘤模型的32只荷瘤兔随机分为4组(8只.组-1):A组,不作任何处理;B组,使用单纯核素131I治疗;C组,使用单纯低频超声微泡治疗;D组,应用核素131I联合低频超声微泡连续治疗。在2周治疗期间连续进行B超检查,观察各组肿瘤生长及体积变化情况。核素治疗后第1、2、4、8、14天分别对B、D两组行单光子发射型电子计算机断层显像(SPECT),并计算不同时间肿瘤区放射性计数值。治疗2周后取部分肿瘤组织行病理学观察。结果:B、C、D 3组肿瘤体积及增长率均小于A组(P<0.05);B组放射性计数的衰减率明显高于D组(P<0.05);病理学检查发现B、C、D组坏死较A组严重,其中D组最明显。结论:核素131I联合低频超声微泡治疗时能够产生协同效应,明显提高疗效。
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| 关 键 词： | 放射性核素131I 低频超声微泡剂 VX2肝肿瘤 电离生物学效应 超声空化效应 兔 |
Research on treating the rabbit bearing VX2 liver tumor by radionuclide 131I combined with low frequency supersonic microbubble agent |
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| XU Guo-hou,DU Ming-hua,ZHONG Ying,Qi Ning. Research on treating the rabbit bearing VX2 liver tumor by radionuclide 131I combined with low frequency supersonic microbubble agent[J]. Journal of Southeast Univ: Medical Sci Ed, 2011, 30(3): 486-490. DOI: 10.3969/j.issn.1671-6264.2011.03.021 |
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| Authors: | XU Guo-hou DU Ming-hua ZHONG Ying Qi Ning |
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| Affiliation: | XU Guo-hou,DU Ming-hua,ZHONG Ying,Qi Ning(Department of Nuclear Medicine,Zhongda Hospital,Southeast University,Nanjing 210009,China) |
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| Abstract: | Objective: To investigate the therapeutic effects of radionuclide 131I in the treatment of the curative inoculation in New Zealand big white rabbit liver left leaf VX2 tumor when combined with low frequency supersonic microbubble agent.Methods: The New Zealand big white rabbits which successfully established the VX2 tumor of liver model were divided into 4 groups stochastically(8 rabbits in each group): group A was blank control group(did not make any processing),group B(the pure radionuclide 131I treatment... |
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| Keywords: | radionuclide 131I low frequency supersonic microbubble agent VX2 liver tumor ionization biology effect supersonic cavitation effect rabbits |
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