| 急性冠脉综合征患者血清糖化白蛋白和单核细胞趋化蛋白水平变化的临床意义 |
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| 引用本文： | 张丽,冯毅,马根山.急性冠脉综合征患者血清糖化白蛋白和单核细胞趋化蛋白水平变化的临床意义[J].东南大学学报(医学版),2011,30(2):324-327. |
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| 作者姓名： | 张丽 冯毅 马根山 |
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| 作者单位： | 1. 东南大学附属第二医院,心内科,江苏,南京,210009
2. 东南大学附属中大医院,心内科,江苏,南京,210009 |
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| 基金项目： | 江苏省卫生厅开放课题基金 |
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| 摘 要： | 目的:探讨急性冠脉综合征(acute coronary syndrome,ACS)患者外周血糖化白蛋白(glycated albu-min,GA)、单核细胞趋化蛋白1(monocyte chemoattractant protein-1,MCP-1)水平的变化与ACS发生发展的关系。方法:应用硝基四氮唑兰(NBT)显色法和酶联免疫吸附法分别测定46例ACS患者(ACS组)、32例稳定型心绞痛患者(stable angina pectoris,SAP组)及30例有胸痛、胸闷等症状但冠脉造影正常的患者(对照组)血中GA和MCP-1水平的变化,并分析冠状动脉的病变情况。结果:ACS组血GA、MCP-1水平明显高于SAP组及对照组(均P<0.01);ACS组冠状动脉狭窄程度积分高于SAP组(P<0.05);ACS组血清GA与MCP-1水平有明显相关性(r=0.721,P<0.01)。结论:血清GA、MCP-1水平可用于预测ACS的发生,GA和MCP-1在ACS的发生和发展中有重要作用。
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| 关 键 词： | 急性冠脉综合征 糖化白蛋白 单核细胞趋化蛋白1 |
Changes and it′s clinical significance of GA and MCP-1 in peripheral blood of patients with acute coronary syndrome |
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| ZHANG Li,FENG Yi,MA Gen-shan.Changes and it′s clinical significance of GA and MCP-1 in peripheral blood of patients with acute coronary syndrome[J].Journal of Southeast Univ: Medical Sci Ed,2011,30(2):324-327. |
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| Authors: | ZHANG Li FENG Yi MA Gen-shan |
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| Institution: | ZHANG Li1,FENG Yi2,MA Gen-shan2 (1.Department of Cardiology,the second Hospital Affilicated to Southeast University,Nanjing 210009,China,2.Department of Cardiology,Zhongda Hospital,Southeast University,China) |
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| Abstract: | Objective: To explore the correlation between glycated albumin(GA),monocyte chemoattractant protein-1(MCP-1) and acute cronary syndrome(ACS).Methods: The levels of GA and MCP-1 in the peripheral blood were measured in 46 patients with ACS(ACS group),32 patients with stable angina pectoris(SAP group) and 30 patients with chest discomfort and normal coronary angiography(control group) by NBT color and enzyme-linked immunosorbent assay(ELISA).The aspects of coronary artery lesions were analyzed.Results: The le... |
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| Keywords: | acute coronary syndrome glycated albumin monocyte chemoattractant protein-1 |
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