泮托拉唑治疗反流性食管炎疗效观察

目的:评价并与奥美拉唑比较泮托拉唑治疗反流性食管炎的疗效和安全性。方法:60例胃镜诊断的反流性食管炎患者,随机分为2组,每天分别口服泮托拉唑胶囊40mg和奥美拉唑肠溶片40mg,于治疗4周和8周后观察反酸、烧心、反食等症状的改善情况,并复查胃镜,观察镜下治愈率,详细记录不良反应。结果:治疗4周后,两组症状明显改善,症状记分较治疗前明显下降(P<0.01)。治疗4周、8周后,泮托拉唑组症状改善总有效率分别为83.3%、93.3%,对照组为76.7%、86.7%,两组比较无显著性差异(P>0.05);泮托拉唑组治愈率分别为60.0%、83.3%,奥美拉唑组为53.3%、76.7%,两组比较无显著性差异(P>0.05)。两组患者均能良好耐受,末发现严重的不良反应。不良反应率泮托拉唑组为3.3%,奥美拉唑组为6.7%,两组比较无显著性差异(P>0.05)。结论:泮托拉唑是治疗反流性食管炎安全、有效的药物。

The effects of pantoprazole in patients with reflux esophagitis

objective:To compare the efficacy and safety of pantoprazole with that of omeprazole in patients with reflux esophagitis disease. Methods:60 patients with endoscopically confirmed reflux esophagitis were enrolled. They were randomly divided into two groups. 30 patients were treated with a once-daily dose of pantoprazole 40 mg in the treatment groups. 30 patients were treated with a once-daily dose of omeprazole 40 mg in the control group,and reflux symptoms including regurgitation,heartburn and food reflux were evaluated after 4 and 8 weeks. And endoscopy was performed to study the healing rate. Results:After 4 weeks treatment ,the symptoms improved significantly,and symptom scores were greatly decreased in both groups(P<0.01) . The total effective rate of symptom improvement was 83.3%,93.3% after 4,8 weeks in the treatment groups ,and 76.7%,86.7% in the control group.There was no difference between two groups(P>0.05). The healing rate was 60.0%,83.3% after 4,8 weeks in the treatment group,and 53.3%,76.7% in the control group.There was no difference between two groups(P>0.05),The rate of side effects were 3.3% in the treatment group,6.7% in the control group.There was no difference between two groups(P>0.05). Conclusion:Pantoprazole is an effective and safe drug for reflux esophagitis.