地佐辛与吗啡用于妇科术后硬膜外镇痛的临床效果比较

目的比较地佐辛与吗啡分别用于妇科手术后硬膜外镇痛的镇痛效果和副作用。方法选择择期妇科手术需要硬膜外镇痛的患者60例(ASAⅠ~Ⅱ级)。随机分成M组(吗啡组)和D组(地佐辛组),30例/组。镇痛药:M组0.004%吗啡+0.15%罗哌卡因+0.01%地塞米松;D组0.0075%地佐辛+0.15%罗哌卡因+0.01%地塞米松,均用PCA泵(100 mL)以LCP模式行PCEA。观察2组患者术后镇痛期间的镇痛效果和副反应如恶心呕吐、皮肤瘙痒、嗜睡、呼吸抑制等。结果 2组配方术后镇痛效果相当,但D组术后恶心呕吐、皮肤瘙痒等不良反应发生率明显低于M组(P<0.05)。结论地佐辛用于妇科术后硬膜外镇痛与吗啡相比,镇痛效果相当,副作用发生率更少,更适合与妇科女性患者的术后镇痛。

A comparative study of effects of Dezocine and Morphine on epidural analgesia after gynecological surgery

Objective To compare the effects of Dezocine and Morphine on epidural analgesia after gynecological surgery.Methods 60 ASA Ⅰ～Ⅱ female patients who needed epidural analgesia when undergoing elective gynecological surgery were involved in this comparative study.They were randomized into M group and D group with 30 patients per group.The patients in M group were treated with 0.004% Morphine,0.15% Ropivacaine,and 0.01% Dexamethasone. The patients in D group were treated with 0.0075% Dezocine,0.15% Ropivacaine,and 0.01% Dexamethasone.Patient-control epidural analgesia(PCEA) was provided to patients in both groups by PCA pump(100 mL) at LCP model.After treatment,patients in both groups were observed for analgesia effects and side effects such as nausea,vomiting,pruritus,drowsiness,respiratory depression,etc. Results After treatment,it achieved satisfactory analgesia effects for patients in both groups(P>0.05).However,the incidence of adverse reactions after surgery(such as nausea,vomiting,and pruritus) of D group was obviously lower than that of M group(P<0.05).Conclusion Compared with Morphine,Dezocine has equivalent satisfactory analgesia effects and less side effects on epidural analgesia after gynecological surgery,indicating that Dezocine is more suitable for epidural analgesia after gynecological surgery.