| Institution: | 1.Department of Radiological and Medical Laboratory Sciences,Nagoya University Graduate School of Medicine,Nagoya,Japan;2.Division of Clinical Radiology Service,Kyoto University Hospital,Kyoto,Japan;3.Brain & Mind Research Center,Nagoya University,Nagoya,Japan;4.Department of Fundamental Development for Advanced Low Invasive Diagnostic Imaging,Nagoya University, Graduate School of Medicine,Nagoya,Japan;5.Department of Radiology,Hamamatsu University Hospital,Shizuoka,Japan;6.Department of Diagnostic Radiological Technology,Iwata City Hospital,Shizuoka,Japan;7.Department of Neurosurgery,Komaki City Hospital,Komaki,Japan;8.Department of Neurosurgery,Iwata City Hospital,Shizuoka,Japan;9.Renaissance of Technology Corporation,Shizuoka,Japan;10.Department of Systems and Control Engineering, School of Engineering,Tokyo Institute of Technology,Tokyo,Japan;11.Department of Neurosurgery,Nagoya University Graduate School of Medicine,Nagoya,Japan |
| Abstract: | PurposeWe performed computational fluid dynamics (CFD) for patients with and without paraclinoid internal carotid artery (ICA) aneurysms to evaluate the distribution of vascular biomarkers at the aneurysm initiation sites of the paraclinoid ICA.MethodsThis study included 35 patients who were followed up for aneurysms using 3D time of flight (TOF) magnetic resonance angiography (MRA) and 3D cine phase-contrast MR imaging. Fifteen affected ICAs were included in group A with the 15 unaffected contralateral ICAs in group B. Thirty-three out of 40 paraclinoid ICAs free of aneurysms and arteriosclerotic lesions were included in group C. We deleted the aneurysms in group A based on the 3D TOF MRA dataset. We performed CFD based on MR data set and obtained wall shear stress (WSS), its derivatives, and streamlines. We qualitatively evaluated their distributions at and near the intracranial aneurysm initiation site among three groups. We also calculated and compared the normalized highest (nh-) WSS and nh-spatial WSS gradient (SWSSG) around the paraclinoid ICA among three groups.ResultsHigh WSS and SWSSG distribution were observed at and near the aneurysm initiation site in group A. High WSS and SWSSG were also observed at similar locations in group B and group C. However, nh-WSS and nh-SWSSG were significantly higher in group A than in group C, and nh-SWSSG was significantly higher in group A than in group B.ConclusionOur findings indicated that nh-WSS and nh-SWSSG were good biomarkers for aneurysm initiation in the paraclinoid ICA. |
