| 猪牙皂总皂苷的镇痛抗炎作用和免疫抑制活性 |
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| 引用本文： | 焦晓兰,朱文龙,殷志琦,夏玉凤,戴岳. 猪牙皂总皂苷的镇痛抗炎作用和免疫抑制活性[J]. 中药药理与临床, 2011, 0(3): 59-62 |
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| 作者姓名： | 焦晓兰 朱文龙 殷志琦 夏玉凤 戴岳 |
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| 作者单位： | 中国药科大学中药药理教研室;中国药科大学天然药化教研室;中国药科大学中药分析教研室; |
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| 基金项目： | 国家“重大新药创制”科技重大专项资助项目(编号:2009ZX09103-392); 江苏高校优势学科建设工程资助项目 |
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| 摘 要： | 目的:研究猪牙皂总皂苷的镇痛、抗炎作用及免疫调节活性,为将其研制成治疗类风湿关节炎的药物提供理论依据。方法:采用小鼠扭体法、热板法考察镇痛作用,采用二甲苯致小鼠耳廓肿胀法、角叉菜胶致大鼠足肿胀法和大鼠棉球肉芽肿法考察抗炎作用,采用小鼠血清溶血素法、绵羊红细胞致小鼠迟发型足跖肿胀法考察免疫调节作用。结果:猪牙皂总皂苷(50,100,200mg/kg)灌胃给药,明显减少醋酸所致小鼠扭体反应次数,提高小鼠在热板的痛阈;对二甲苯致小鼠耳廓肿胀、角叉菜胶致大鼠足跖肿胀和大鼠棉球肉芽肿,猪牙皂总皂苷均呈现显著的抑制作用。此外,猪牙皂总皂苷显著降低绵羊红细胞所致小鼠血清溶血素水平,抑制绵羊红细胞所致小鼠迟发型足跖肿胀。结论:猪牙皂总皂苷具有镇痛、抗炎和免疫抑制作用。
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| 关 键 词： | 猪牙皂总皂苷 镇痛 抗炎 免疫调节 |
Analgesic,anti-inflammatory and immunoregulatory effects of saponin fraction from Gleditsia sinensis |
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| Jiao Xiaolan,Zhu Wenlong,Yin Zhiqi,Xia Yufeng,Dai Yue. Analgesic,anti-inflammatory and immunoregulatory effects of saponin fraction from Gleditsia sinensis[J]. Pharmacology and Clinics of Chinese Materia Medica, 2011, 0(3): 59-62 |
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| Authors: | Jiao Xiaolan Zhu Wenlong Yin Zhiqi Xia Yufeng Dai Yue |
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| Affiliation: | Jiao Xiaolan1,Zhu Wenlong1,Yin Zhiqi2,Xia Yufeng3,Dai Yue1(1 Department of Pharmacology of Chinese Materia Medica,China Pharmaceutical University,Nanjing 210009,2 Department of Medicinal Chemistry of Natural Products,3 Department of Chinese Materia Medica Analysis,Nanjing 210009) |
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| Abstract: | Objective:To study the analgesic,anti-inflammatory and immunoregulatory activities of saponin fraction from Gleditsia sinensis(SFGS).Methods:The analgesic activity of SFGS was observed by acetic acid-induced writhing and hot plate test.Three animal models,including swelling of mouse ear lobes caused by xylene,paw edema caused by carrageenan and cotton pellet granuloma in rats,were used to determine the anti-inflammatory activities of SFGS.Moreover,the immunoregulatory effects of SFGS were evaluated by serum... |
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| Keywords: | SFGS(saponin fraction from Gleditsia sinensis) analgesic anti-inflammatory action immunoregulation |
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