| 惊天宁注射液在大鼠体内药代动力学研究 |
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| 引用本文： | 孙兰,李家春,李芳,尚强,王振中. 惊天宁注射液在大鼠体内药代动力学研究[J]. 中药药理与临床, 2011, 0(4): 80-83 |
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| 作者姓名： | 孙兰 李家春 李芳 尚强 王振中 |
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| 作者单位： | 江苏康缘药业股份有限公司; |
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| 摘 要： | 目的:研究惊天宁注射液中黄芩苷及芍药苷在大鼠体内的药动学,为临床用药提供参考。方法:惊天宁注射液静脉注射给予大鼠,不同时间点采血,甲醇沉淀法处理血浆样品,高效液相色谱方法测定黄芩苷及芍药苷血药浓度,并用DAS数据处理软件计算动力学参数。结果:惊天宁注射液静脉给药后,黄芩苷和芍药苷血药浓度-时间曲线在大鼠体内过程均符合二室模型,黄芩苷和芍药苷药时曲线下面积在实验剂量范围内符合线性药代动力学特征。结论:所建立的方法准确、灵敏度高,专属性好,可用于黄芩苷和芍药苷的体内血浆药物浓度的同时分析。血浆中黄芩苷及芍药苷消除较快。
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| 关 键 词： | 惊天宁注射液 黄芩苷 芍药苷 药代动力学 |
Study on pharmacokinetics of Jingtianning Injection in rats |
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| Sun Lan,Li Jiachun,Li Fang,Shang Qiang,Wang Zhen zhong. Study on pharmacokinetics of Jingtianning Injection in rats[J]. Pharmacology and Clinics of Chinese Materia Medica, 2011, 0(4): 80-83 |
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| Authors: | Sun Lan Li Jiachun Li Fang Shang Qiang Wang Zhen zhong |
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| Affiliation: | Sun Lan,Li Jiachun,Li Fang,Shang Qiang,Wang Zhen zhong(Jiangsu Kanion Pharmaceutical Co.,Ltd.Lianyungang 222001) |
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| Abstract: | Objective:To study the pharmacokinetics features of baicalin and paeoniflorin from Jingtianning Injection in rats,and to provide reference for clinic.Methods:The rats received intravenous injection of Jingtianning,and its plasma sample was collected in different time.The plasma samples of rats were prepared by methanol precipitation.A high-performance liquid chromatographic method was developed to determine the Plasma concentration of baicalin and paeoniflorin,and the Pharmacokinetic parameters were perform... |
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| Keywords: | Jingtianning Injection baicalin paeoniflorin pharmacokinetics |
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