| 叶黄素对顺铂所致大鼠急性肝损伤的防治作用 |
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| 引用本文： | 李文甫,张慧珠,张文丽,刘淑梅,张博男,韩淑英. 叶黄素对顺铂所致大鼠急性肝损伤的防治作用[J]. 中药药理与临床, 2011, 0(2): 51-53 |
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| 作者姓名： | 李文甫 张慧珠 张文丽 刘淑梅 张博男 韩淑英 |
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| 作者单位： | 河北联合大学医学部; |
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| 摘 要： | 目的:观察叶黄素(LU)对顺铂(CP)诱导的大鼠急性肝损伤的保护作用。方法:将30只SD大鼠随机分为5组,分别为对照组、顺铂组、不同剂量叶黄素(10mg/kg、20mg/kg和40mg/kg)+顺铂组。大鼠连续灌胃叶黄素10天,第7天灌胃后l h腹腔注射顺铂(5mg/kg)。顺铂处理后,在第5天采血,测定血清谷丙转氨酶(ALT)、谷草转氨酶(AST)。采血后处死动物,测定肝脏系数、肝匀浆丙二醛(MDA)、一氧化氮(NO)、还原型谷胱甘肽(GSH)含量和超氧化物歧化酶(SOD)活力,同时观察肝组织结构变化。结果:肝损伤模型组大鼠血清ALT、AST含量均明显高于对照组,肝组织匀浆中MDA及NO含量显著增加,而GSH含量及SOD活性显著下降。叶黄素可降低肝损伤大鼠血清ALT及AST水平,降低肝组织匀浆MDA及NO水平,提高组织GSH含量及SOD活性,并可改善顺铂损伤大鼠肝病理组织学变化,随着叶黄素剂量增加,其保护作用增强。结论:叶黄素通过抗氧化作用减轻顺铂诱导的大鼠肝损伤作用。
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| 关 键 词： | 叶黄素 顺铂 肝毒性 抗氧化剂 |
Protective effects of lutein on cisplatin-induced acute hepatotoxicity in rats |
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| Li Wenfu,Zhang Huizhu,Zhang Wenli,Liu Shumei,Zhang Bonan,Han Shuying. Protective effects of lutein on cisplatin-induced acute hepatotoxicity in rats[J]. Pharmacology and Clinics of Chinese Materia Medica, 2011, 0(2): 51-53 |
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| Authors: | Li Wenfu Zhang Huizhu Zhang Wenli Liu Shumei Zhang Bonan Han Shuying |
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| Affiliation: | Li Wenfu,Zhang Huizhu,Zhang Wenli,Liu Shumei,Zhang Bonan,Han Shuying (Medical Devision of Hebei United College,Tangshan 063000) |
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| Abstract: | Objective: To investigate the protective effect of lutein(LU) on cisplatin(CP)-induced acute hepatotoxicity in rats.Methods: Sprague-Dawley rats were randomly divided into 5 groups(6 rats in each).Animals received LU by gavage for 10 days.Animals were intraperitoneally administration of CP(5mg/kg) after 1 h of the seventh administration of LU(10mg/kg,20mg/kg and 40mg/kg).Blood alanine aminotransferase(ALT) and aspartate aminotransferase(AST) were determined on fifth day after CP treatment.All animals were k... |
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| Keywords: | lutein cisplatin hepatotoxicity antioxidant |
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