| 参芍降脂片对高脂血症小鼠血脂水平及肝功能的影响 |
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| 引用本文： | 胡慧明,陈素红,吕圭源,唐礼可,王寅,郭殿武.参芍降脂片对高脂血症小鼠血脂水平及肝功能的影响[J].中药药理与临床,2011(2):113-114. |
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| 作者姓名： | 胡慧明 陈素红 吕圭源 唐礼可 王寅 郭殿武 |
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| 作者单位： | 温州医学院;浙江中医药大学;杭州民生药业集团有限公司; |
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| 基金项目： | 国家十一五重大新药创制项目中药复方药理学研究及药效学评价关键技术(2009ZX09502-016) |
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| 摘 要： | 目的:探讨参芍降脂片对蛋黄乳剂腹腔注射致急性高脂血症模型小鼠的血脂水平及肝功能指标的影响。方法:采用75%蛋黄乳剂腹腔注射建立急性高脂血症模型,连续灌胃给予参芍降脂片11天,末次给药2h后,除正常对照组外其余各组腹腔注入新鲜蛋黄乳剂0.1ml/10g,20h后摘眼球取血,检测血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)含量。结果:参芍降脂片300mg/kg可降低小鼠血清TC、TG、LDL-C、ALT、AST,升高HDL-C/TC比值;参芍降脂片150mg/kg可显著升高小鼠血清HDL-C/TC;参芍降脂片75mg/kg可显著降低小鼠血清TC、TG、LDL-C、ALT、AST,升高HDL-C/TC比值。结论:参芍降脂片能改善蛋黄乳剂致急性高脂血症模型小鼠的血脂水平及肝功能。
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| 关 键 词： | 参芍降脂片 蛋黄乳剂 高脂血症 血脂 |
Effect of Shenshao Hypolipidemic Tablet on blood lipid levels and liver fuction of hyperlipidemia mice |
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| Hu Huiming,Chen Suhong,Lv Guiyuan ,Tang Like,Wang Yin,Guo Dianwu.Effect of Shenshao Hypolipidemic Tablet on blood lipid levels and liver fuction of hyperlipidemia mice[J].Pharmacology and Clinics of Chinese Materia Medica,2011(2):113-114. |
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| Authors: | Hu Huiming Chen Suhong Lv Guiyuan Tang Like Wang Yin Guo Dianwu |
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| Institution: | Hu Huiming1,Chen Suhong1,Lv Guiyuan 2,Tang Like3,Wang Yin2,Guo Dianwu3(1Wenzhou Medical College,Wenzhou 325035,2Zhejiang Chinese Medical University,Hangzhou 310053,3Minsheng Pharmaceutical Group Limited Company in Hangzhou,Hangzhou 310011) |
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| Abstract: | Objective:To research the effect of Shenshao Hypolipidemic Tablet(DSS) on blood lipid and liver function in hyperlipidemia mice by intraperitioneal injection egg-yolk emultion.Methods:Mice were injected with 75% egg-yolk emultion to establish hyperlipidemia model.The treatment groups were simultaneously administered with DSS for 11 days.After 2 hours of the last administration,the experimental groups were injected with 75% egg-yolk emultion by 0.1ml/10g except normal control.After 20 hours,the blood were co... |
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