| 真武汤对阿霉素肾病大鼠治疗作用研究 |
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| 引用本文： | 李莎莎,韩凌,肖雪,黎莉,王义明,罗国安. 真武汤对阿霉素肾病大鼠治疗作用研究[J]. 中药药理与临床, 2011, 0(2): 16-19 |
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| 作者姓名： | 李莎莎 韩凌 肖雪 黎莉 王义明 罗国安 |
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| 作者单位： | 广东省中医院中心实验室;南开大学药学院;清华大学生命科学与医学研究院; |
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| 摘 要： | 目的:通过检测阿霉素肾病(adriamycin nephropathy,AN)大鼠的肾比重、血液生化指标及观察肾脏组织病理切片,探讨真武汤对AN大鼠的治疗作用。方法:将大鼠随机分为5组,除正常对照组外,其余大鼠尾静脉注射阿霉素造模大鼠随机分为4组:模型组、缬沙坦组(24mg/kg)、真武汤低剂量组(5.3g生药/kg)、真武汤高剂量组(15.9 g生药/kg),检测其尿蛋白含量。采用HE染色的方法观察肾脏组织形态学变化,检测大鼠的肾比重及0、14、28d大鼠24h尿量及血液生化指标。结果:真武汤5.3g生药/kg可增加AN大鼠24h尿量,真武汤15.9g生药/kg不仅可增加24h尿量而且可以缓解低蛋白血症、降低肾比重、改善肾小球萎缩硬化充血及髓质区蛋白管型等病理变化。结论:真武汤对AN大鼠肾水肿、肾功能下降、肾组织病理性变化具有正相调节作用。
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| 关 键 词： | 真武汤 阿霉素肾病 |
Pharmacodynamics study on the effect of Zhenwu Decoction on adriamycin nephropathy rat |
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| Li Shasha,Han Ling,Xiao Xue,,Li Li,Wang Yiming,Luo Guoan. Pharmacodynamics study on the effect of Zhenwu Decoction on adriamycin nephropathy rat[J]. Pharmacology and Clinics of Chinese Materia Medica, 2011, 0(2): 16-19 |
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| Authors: | Li Shasha Han Ling Xiao Xue Li Li Wang Yiming Luo Guoan |
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| Affiliation: | Li Shasha1,Han Ling1,Xiao Xue2,3,Li Li1,Wang Yiming1,Luo Guoan1,3(1 The Central Laboratory of Guangdong Provincial Hospital of Traditional Chinese Medicine,Guangzhou 510120,2 College of Pharmacy Nankai University,Tianjin 300071,3 Institute of Biomedicine,Tsinghua University,Beijing 100084) |
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| Abstract: | Objective: Investigate the therapeutic effects of zhenwu decoction on adriamycin nephropathy rat by detecting kidney proportion of body weight,blood biochemical index and observing the pathological section of kidney.Methods: Besides A group(normal control group),the adriamycin nephropathy rats were divided into 4 groups after positive expression of proteinuria detected : model group,adriamycin nephropathy group treated by valsartan(24mg/kg),adriamycin nephropathy group treated by zhenwu decoction of low dos... |
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