| 叶黄素对二甲基甲酰胺所致小鼠急性肝损伤的保护作用 |
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| 引用本文： | 刘淑梅,刘跃新,张慧珠,勾向博,白静,张晶,温少红. 叶黄素对二甲基甲酰胺所致小鼠急性肝损伤的保护作用[J]. 中药药理与临床, 2011, 0(6): 26-28 |
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| 作者姓名： | 刘淑梅 刘跃新 张慧珠 勾向博 白静 张晶 温少红 |
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| 作者单位： | 河北联合大学基础医学院; |
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| 摘 要： | 目的:用生化及病理学方法研究叶黄素对二甲基甲酰胺(DMF)所致小鼠急性肝损伤的保护作用。方法:将48只小鼠随机分为4组,分别为对照组、DMF模型组、20mg/kg及40mg/kg叶黄素处理组。小鼠连续灌胃叶黄素5天,对照组和DMF模型组给予等体积玉米油。灌胃叶黄素3天后,除对照组腹腔注射生理盐水,其余三组均一次性腹腔注射1.5g/kg DMF。DMF染毒48h后,所有动物内眦取血,处死后剖取肝脏,检测其AST、ALT等指标。结果:DMF模型组小鼠血清ALT和AST活性显著升高,肝脏组织匀浆中MDA含量明显增加,SOD活性升高。叶黄素可降低血清AST及ALT活性及肝组织SOD活性、MDA水平,改善肝脏损伤小鼠病理组织学变化。结论:叶黄素通过抗氧化作用对DMF所致肝脏毒性具有一定保护作用。
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| 关 键 词： | 叶黄素 二甲基甲酰胺 肝毒性 抗氧化剂 |
Protective effect of lutein on acute hepatotoxicity induced by N,N-dimethylformamide in mice |
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| Liu Shumei,Liu Yuexin,Zhang Huizhu,Gou Xiangbo,Bai Jing,Zhang Jing,Wen Shaohong. Protective effect of lutein on acute hepatotoxicity induced by N,N-dimethylformamide in mice[J]. Pharmacology and Clinics of Chinese Materia Medica, 2011, 0(6): 26-28 |
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| Authors: | Liu Shumei Liu Yuexin Zhang Huizhu Gou Xiangbo Bai Jing Zhang Jing Wen Shaohong |
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| Affiliation: | Liu Shumei,Liu Yuexin,Zhang Huizhu,Gou Xiangbo,Bai Jing,Zhang Jing,Wen Shaohong(Basic Medical College of Hebei United University,Tangshan 063000) |
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| Abstract: | Objective:The aim of this study was to investigate the possible protective role of lutein on N,N-dimethylformamide(DMF) induced hepatotoxicity in mice using biochemistry and pathological approaches.Methods:48 mice were randomly divided into four groups,eg control group,DMF group,DMF+20mg/kg lutein group,and DMF+40mg/kg lutein group.The first group received no medication and was regarded as the control group.The second group was intraperitoneally(ip) injected with a single dose of 1.5g/kg DMF.The third and f... |
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| Keywords: | lutein N N-dimethylformamide hepatotoxicity antioxidant |
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