打箭菊对D-半乳糖胺所致大鼠急性肝损伤的保护作用 |
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引用本文: | 林朝展,陈德金,贝日·泽仁达瓦,胡敏,李小翚,祝晨蔯,康萨·索朗其美. 打箭菊对D-半乳糖胺所致大鼠急性肝损伤的保护作用[J]. 中药药理与临床, 2011, 0(5): 79-81 |
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作者姓名: | 林朝展 陈德金 贝日·泽仁达瓦 胡敏 李小翚 祝晨蔯 康萨·索朗其美 |
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作者单位: | 广州中医药大学中药学院广中尖峰天然产物共建实验室;西藏藏医学院藏医药科技研究所; |
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基金项目: | 国家自然科学基金项目资助课题(编号:30960530) |
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摘 要: | 目的:研究藏药打箭菊对D-半乳糖胺(D-galactosamine,D-Gal)所致大鼠急性肝损伤的保护作用。方法:60只大鼠随机分为正常对照组、模型组、高中低剂量给药组、阳性对照组等6个组。给药组按18 g/kg、9 g/kg、4.5 g/kg剂量以打箭菊水提物灌胃;阳性对照组按50 mg/kg联苯双酯灌胃,每天1次,共7天。灌胃给药第6天下午,模型组和给药组按500 mg/kg体重腹腔注射D-Gal一次。第8天,末次给药24 h(腹腔注射36 h)后,测定血清生化指标,并测体重和肝脏重、脾重、胸腺重,求脏器系数,同时切取肝脏检测肝糖原,取肝组织作病理观察。结果:打箭菊18 g/kg、9 g/kg、4.5 g/kg剂量给药组均可显著降低急性肝损伤大鼠血清ALT、AST、ALP水平和TBA、T-Bil含量,促进血清中TP、ALB和肝组织中肝糖原的增加,且中低剂量给药组对肝重量增大和胸腺萎缩有抑制作用。病理检查结果也显示有明显的保肝作用。结论:打箭菊对D-Gal所致大鼠急性肝损伤有保护作用,其作用机制与多环节有关。
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关 键 词: | 打箭菊 D-半乳糖胺 肝损伤 |
Protective effect of Pyrethrum tatsienense(Bur.et Franch.) Ling on acute hepatic injury induced by D-galactosamine in rats |
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Affiliation: | Lin Chaozhan1,Chen Dejin1,Bei ·Riozerendawa2,Hu Min1,Li Xiaohui1,Zhu Chenchen1,Kang·Saoauolangqimei2 (1 College of Chinese Traditional Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510006,2 Science and Technology Institute of Tibetan Medicine,Tibetan Traditional Medical College,Lasa 850000) |
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Abstract: | Objective : To study the protective effects of Pyrethrum tatsienense(Bur.et Franch.) Ling aqueous extract on acute hepatic injury induced by D-galactosamine(D-Gal) in rats.Methods: 60 rats were allocated to control group,model group,low,middle and high dosage group and Bifendate group randomly.In test groups,rats received either PT aqueous extract(18 g/kg,9 g/kg,4.5 g/kg) or Bifendate(50 mg/kg) by gastric perfusion daily for 7 consecutive days.In sixth day,D-Gal(500 mg/kg) was given to rats by intraperitone... |
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Keywords: | Pyrethrum tatsienense(Bur.et Franch.) Ling D-galactosamine acute liver injury |
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