| 益肤凝胶透皮吸收促进剂的筛选研究 |
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| 引用本文： | 杨金艳,吴诗惠,罗明霞. 益肤凝胶透皮吸收促进剂的筛选研究[J]. 中药药理与临床, 2011, 0(2): 115-118 |
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| 作者姓名： | 杨金艳 吴诗惠 罗明霞 |
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| 作者单位： | 四川省中西医结合医院;四川省中医药科学院;安岳县中医院; |
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| 摘 要： | 目的:为了促进益肤凝胶主要有效成分丹皮酚透皮吸收,本文考察了多种透皮促进剂对凝胶中丹皮酚体外透皮吸收的影响。方法:以小鼠离体皮肤微渗透屏障,采用Franz扩散池装置进行体外透皮实验,运用HPLC法测定接受池中药物累积透过量,考察不同接受液与不同透皮促进剂对凝胶中有效成分丹皮酚透皮吸收的影响,筛选最佳透皮促进剂的种类和浓度。结果:以甲醇/生理盐水(1:1)为接受液,渗透速率Js(4.5501±0.4583μg/(cm2.h))明显高于其他接受液(P<0.05);氮酮(Azone)与棕榈酸乙酯(EPM)促进不大(P>0.05),油酸(OA)与丙二醇(PG)明显对促进凝胶中丹皮酚透皮吸收(P<0.05,P<0.01),且丙二醇(PG)为促渗透效果最佳,浓度为5%时,对丹皮酚的促透作用最强,皮肤滞留量最高。结论:5%浓度的丙二醇可促进凝胶中丹皮酚的透皮吸收,可作为本制剂的透皮促进剂。
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| 关 键 词： | 丹皮酚 透皮吸收 透皮促进剂 |
Screening researches on penetration enhancers of Yifu Gel |
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| Yang Jinyan,Wu Shhui,Luo Mingxia. Screening researches on penetration enhancers of Yifu Gel[J]. Pharmacology and Clinics of Chinese Materia Medica, 2011, 0(2): 115-118 |
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| Authors: | Yang Jinyan Wu Shhui Luo Mingxia |
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| Affiliation: | Yang Jinyan1,Wu Shhui2,Luo Mingxia3(1 Sichuan Hospital of Integrated Traditional Chinese Medicine,Chengdu 610041,2 Sichuan Academy of Chinese Medicine Sciences,3 Anyue Hospital of Traditional Chinese Medicine,Ziyang 642350) |
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| Abstract: | Objective:To promote the transdermal absorption of paeonol which is the major active constituent in Yifu Gel,our study investigated the effect of different on the transdermal absorption of paeonol in Yifu Gel in vitro.Method: Using mice skin in vitro as the transdermal barrier and the instrument of Franz diffusion cells,we determined the cumulative amount of the drug in receptor chamber by HPLC.We screened the best type and concentration of the best penetration enhancer by investigating the effect of differ... |
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| Keywords: | paeonol transdermal absorption penetration enhancer |
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