| 去乙酰紫玉盘素通过抑制ERK/MAPK通路抗肝癌增殖 |
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| 引用本文： | 任凤梅,舒秉俊,罗时辉,王鹰,章跃平,徐安.去乙酰紫玉盘素通过抑制ERK/MAPK通路抗肝癌增殖[J].中药药理与临床,2011(3):28-30. |
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| 作者姓名： | 任凤梅 舒秉俊 罗时辉 王鹰 章跃平 徐安 |
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| 作者单位： | 南昌市第二医院; |
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| 基金项目： | 江西省卫生厅中医药科研基金课题(课题编号:2009A075) |
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| 摘 要： | 目的:观察番荔枝内酯去乙酰紫玉盘素(Desacetyluvaricin)对人肝癌细胞HepG2中细胞外信号调节激酶(extracellular signal regulated kinase,ERKs)表达水平的影响,探讨去乙酰紫玉盘素对ERK/MAPK信号传导通路的影响及其抗肝癌增殖的机制。方法:以12.52、5、50μg/ml的Desacetyluvaricin处理HepG2细胞,Western Blot检测ERK、p-ERK蛋白表达水平的变化,分析去乙酰紫玉盘素对ERK/MAPK信号通路的影响。结果:Desacetyluvaricin处理HepG2细胞后,ERK和p-ERK蛋白表达水平明显下降,并呈剂量依赖关系,其中Desacetyluvaricin以50μg/ml的浓度处理HepG2细胞时免疫印迹条带的发光强度最弱,ERK和p-ERK蛋白的表达水平最低。结论:去乙酰紫玉盘素抗肝癌增殖可能与其抑制ERK/MAPK通路有关。
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| 关 键 词： | 番荔枝内酯 ERK/MAPK 肝细胞癌(HCC) |
Desacetyluvaricin resists proliferation of hepatoma cells through inhibiting ERK/MAPK pathway |
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| Ren Fengmei,Shu Bingjun,Luo Shihui,Wang Ying,Zhang Yueping,Xu An.Desacetyluvaricin resists proliferation of hepatoma cells through inhibiting ERK/MAPK pathway[J].Pharmacology and Clinics of Chinese Materia Medica,2011(3):28-30. |
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| Authors: | Ren Fengmei Shu Bingjun Luo Shihui Wang Ying Zhang Yueping Xu An |
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| Institution: | Ren Fengmei,Shu Bingjun,Luo Shihui,Wang Ying,Zhang Yueping,Xu An (Second Hospital of Nanchang,Nanchang 330003) |
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| Abstract: | Objective:To observe the effect of desacetyluvaricin on extracellular signal regulated kinase(ERKs) expression in hepatoma carcinoma HepG2 cells,and explore the mechanisms of the antitumor effects of desacetyluvaricin.Methods:HepG2 cells were treated with desacetyluvaricin,Western Blot was performed to examine the expressions of ERK and p-ERK in the cells.Results :The expression of ERK and p-ERK were significantly lowered in the cells after treatment.Conclusion :desacetyluvaricin can resist proliferation of... |
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| Keywords: | desacetyluvaricin ERK/MAPK hepatocellular carcinoma(HCC) |
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