| 荷叶黄酮治疗小鼠非酒精性脂肪肝的研究 |
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| 引用本文： | 王俊杰,舒洋,龙婷,吴海燕,陈福春,方会龙,蒋显勇.荷叶黄酮治疗小鼠非酒精性脂肪肝的研究[J].中药药理与临床,2011(2):61-64. |
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| 作者姓名： | 王俊杰 舒洋 龙婷 吴海燕 陈福春 方会龙 蒋显勇 |
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| 作者单位： | 湘南学院;湘南学院附属医院;郴州市第一人民医院; |
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| 基金项目： | 湖南省教育厅课题资助项目(编号:10C1246); 郴州市科技计划项目(编号:2008gl03); 湘南学院药理湖南省重点建设学科; 湖南省心脑血管天然药物研究重点实验室资助 |
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| 摘 要： | 目的:研究荷叶黄酮对小鼠非酒精性脂肪肝的治疗作用。方法:以复方高脂饮食建立非酒精性脂肪肝小鼠模型,造模第14d,将60只照模鼠随机分为模型组,阳性对照组(易善复150mg/kg),荷叶黄酮低、中、高剂量治疗组(剂量分别是50,100,200mg/kg)。分别观察荷叶黄酮对非酒精性脂肪肝小鼠的肝指数,血清TC、TG、ALT、AST以及肝脏TC、TG含量,观察小鼠肝组织脂质变性程度。结果:荷叶黄酮治疗42d后,非酒精性脂肪肝小鼠肝指数、血清TC、TG、ALT、AST,肝脏TC、TG含量明显降低(P<0.05或P<0.01),并且具有一定的剂量依赖趋势,其中,荷叶黄酮中、高剂量组肝脏TG水平降低显著,与正常组无统计学差异(P>0.05)。光镜观察结果表明,给予荷叶黄酮的小鼠肝组织脂质变性程度改变明显减轻(P<0.01)。结论:荷叶黄酮具有治疗小鼠非酒精性脂肪肝的作用,其作用机制与降低肝脏TG水平有关。
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| 关 键 词： | 荷叶黄酮 非酒精性脂肪肝 甘油三酯 |
Therapeutic effect of flavonoids in lotus on nonalcoholic fatty liver in mice |
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| Wang Junjie,Shu Yang,Long Ting,Wu Haiyan,Chen Fuchun,Fang Huilong,Jiang Xianyong.Therapeutic effect of flavonoids in lotus on nonalcoholic fatty liver in mice[J].Pharmacology and Clinics of Chinese Materia Medica,2011(2):61-64. |
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| Authors: | Wang Junjie Shu Yang Long Ting Wu Haiyan Chen Fuchun Fang Huilong Jiang Xianyong |
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| Institution: | Wang Junjie1,Shu Yang2,Long Ting1,Wu Haiyan3,Chen Fuchun1,Fang Huilong1,Jiang Xianyong1,3(1Xiangnan University,2Hospital Xiangnan University,3Chenzhou No.1 People's Hospital,Chenzhou 423000) |
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| Abstract: | Aim :To investigate whether flavonoids in lotus leaves had therapeutic effect on nonalcoholic fatty liver and its possible mechanism in mice.Methods :60 male mice models with nonalcoholic fatty liver were successfully established by high fat diet for 60 days and were randomly divided into five groups, model groups, essentiale groups, flavonoids in lotus groups(50,100,200mg/kg).The normal group fed with basic animal feeds. The experimental mice were treated with flavonoids in lotus and essentiale for42 days ... |
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| Keywords: | flavonoids in lotus nonalcoholic fatty liver triglyceride |
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