| 毛囊干细胞参与创面修复及相关的信号转导通路 |
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| 引用本文： | 王洪涛,陈璧,胡大海. 毛囊干细胞参与创面修复及相关的信号转导通路[J]. 中国修复重建外科杂志, 2007, 21(1): 90-93 |
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| 作者姓名： | 王洪涛 陈璧 胡大海 |
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| 作者单位： | 第四军医大学西京医院烧伤与皮肤外科,西安,710032 |
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| 摘 要： | 目的对毛囊干细胞（hair follicle stem cell，FSC）参与创面修复过程及相关信号转导通路的研究进展进行综述。方法广泛查阅近年国内外相关文献，对FSC定位、细胞表面标记物、与创面修复的关系及相关信号转导通路研究进展进行回顾总结与分析。结果FSC在维持毛囊循环和创面修复中具有重要作用。已知参与调控这一过程的信号转导通路有Wnt、骨形成蛋白／转化生长因子β．Notch、Shh和成纤维细胞生长因子等。结论FSC在创面修复等再生医学中有广阔的应用前景，有关其增殖分化调控的研究将成为创面修复及组织工程等领域内新的研究热点。
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| 关 键 词： | 毛囊干细胞 创面修复 信号通路 |
| 修稿时间： | 2006-03-15 |
ROLE OF HAIR FOLLICLE STEM CELL IN WOUND HEALING AND CORRELATIVE SIGNALS |
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| WANG Hongtao,CHEN Bi,HU Dahai. ROLE OF HAIR FOLLICLE STEM CELL IN WOUND HEALING AND CORRELATIVE SIGNALS[J]. Chinese journal of reparative and reconstructive surgery, 2007, 21(1): 90-93 |
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| Authors: | WANG Hongtao CHEN Bi HU Dahai |
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| Affiliation: | Department of Burn and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an Shaanxi, 710032, P. R. China. |
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| Abstract: | OBJECTIVE: To review the research progress of hair follicle stem cell (FSC) in wound healing and correlative signals. METHODS: The advances in the FSC location, characters, relations with wound repair and correlative singals were introduced based on the recent related literature. RESULTS: FSC played an important role in hair follicle cycle and wound healing. The correlative signals maybe Wnt, bone morphogenetic protein/transforming growth factor beta, Norch, Shh and fibroblast growth factor. CONCLUSION: The multipotency and plasticity of FSC offer a new way in regeneration medicine and the signals in cell proliferation and differentiation will be the new focus in future research. |
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| Keywords: | Hair follicle stem cell Wound healing Signals |
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