| 蝇蕈醇小脑齿状-中位核微注射对豚鼠经典眨眼条件反射建立的影响 |
| |
| 引用本文： | 林曦,胡波,杨丽,隋建峰. 蝇蕈醇小脑齿状-中位核微注射对豚鼠经典眨眼条件反射建立的影响[J]. 第三军医大学学报, 2008, 30(6): 499-502 |
| |
| 作者姓名： | 林曦 胡波 杨丽 隋建峰 |
| |
| 作者单位： | 1. 第三军医大学基础医学部生理学教研室,重庆,400038
2. 第三军医大学西南医院神经外科,全军神经系统疾病微创诊治专科中心,重庆,400038 |
| |
| 摘 要： | 目的 观察小脑齿状-中位核在豚鼠经典眨眼条件反射建立过程中的作用.方法 采用500 ms正弦波纯音和100 ms束状氧气流的配对刺激,训练豚鼠建立经典眨眼条件反射.在条件反射训练的第4～6天,向豚鼠双侧小脑齿状-中位核微注射蝇蕈醇.整个实验过程中,使用高分辨率的张力换能器检测豚鼠的眨眼反应.结果 ①蝇蕈醇注射组豚鼠训练第4～6天的条件反应率均显著低于第3训练日水平(P1=0.005,P2=0.004,P3=0.010);②蝇蕈醇注射组豚鼠训练第7、8天条件反应率仅分别相当于对照组豚鼠第4、5训练日水平(P1=O.061,P2=0.669);③在此过程中,蝇蕈醇注射组豚鼠非条件眨眼反应的幅度和峰潜伏期均无显著变化(P1=0.926,P2=0.939).结论 小脑齿状一中位核是运动性学习神经回路的重要组成部分,控制着眨眼条件反应的获得和表达.
|
| 关 键 词： | 小脑 齿状-中位核 眨眼 条件反射 蝇蕈醇 |
| 文章编号： | 1000-5404(2008)06-0499-04 |
| 修稿时间： | 2007-10-23 |
Microinjection of Muscimol into cerebellular dentate-interpositus nuclei affects acquisition of classical eyeblink conditioning in guinea pigs |
| |
| LIN Xi,HU Bo,YANG Li,SUI Jian-feng. Microinjection of Muscimol into cerebellular dentate-interpositus nuclei affects acquisition of classical eyeblink conditioning in guinea pigs[J]. Acta Academiae Medicinae Militaris Tertiae, 2008, 30(6): 499-502 |
| |
| Authors: | LIN Xi HU Bo YANG Li SUI Jian-feng |
| |
| Affiliation: | 1 Department of Physiology;College of Medicine;2 Department of Neurosurgery;Southwest Hospital;Third Military Medical University;Chongqing 400038;China |
| |
| Abstract: | Objective To investigate the role of cerebellar dentate-interpositus (D-I) nuclei during acquisition of classical eyeblink conditioning in guinea pigs. Methods A 500 ms tone conditioned stimulus (CS) was paired with a 100 ms corneal oxygen-puff unconditioned stimulus (US) in a delay paradigm. Guinea pigs were trained daily to acquire the classically conditioned eyeblink responses. Micorinjections of Muscimol into bilateral cerebellar D-I nuclei were performed during the 4-6 day of training session. A high-r... |
| |
| Keywords: | cerebellum dentate-interpositus nuclei eyeblink conditioning Muscimol |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
