| IL-17参与EAU发病及其作用探讨 |
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| 引用本文： | 钱丽丽,张凤蕴,郭涛,黄琪,赵瑞波,王丽群,任欢.IL-17参与EAU发病及其作用探讨[J].国际免疫学杂志,2008,31(2). |
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| 作者姓名： | 钱丽丽 张凤蕴 郭涛 黄琪 赵瑞波 王丽群 任欢 |
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| 作者单位： | 哈尔滨医科大学免疫学教研室,150081 |
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| 摘 要： | 目的 诱导建立大鼠EAU模型,探讨Th17是否参与EAU发病及其可能的作用机制.方法 用视网膜S抗原与Freund完全佐剂免疫大鼠诱导EAU模型.观察EAU发作时间、EAU临床评分及组织病理学改变,并采用免疫组织化学SP法,检测EAU组和对照组动物眼后部葡萄膜视网膜IL-17的表达.结果 EAU组动物的眼睛在免疫后不同时间发生不同程度的炎症(发病率为100%),临床评分为(3.14±0.61),具有阳性体征者均有葡萄膜视网膜组织病理学改变,模型建立成功.经免疫组织化学染色发现,EAU组IL-17表达阳性率为86%.结论 Th17在EAU的发病机制中可能发挥一定作用.
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| 关 键 词： | 实验性自身免疫性葡萄膜视网膜炎(EAU) 发病机制 |
Involvement of IL-17 in EAU pathogenesis |
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| Abstract: | Objective To induce experimental autoimmune uveoretinitis(EAU)for discuss if Th17 involve in EAU pathogenesis and the possible function mechanism of it.Methods EAU was induced by immunization with retinal S-antigen and complete Freund's adjuvant. Immunohistochemistry was employed to detect the expression of IL-17 in both EAU group and control group.Results EAU was induced after immunization with S-Ag(The mobility was 100%),clinical scoring is 3.14±0.61,Rat EAU models were constructed in 14 out of 14 immunized animals,with which clinical scoring were applied.Expression of IL-17 was detected in EAU group by Immunohistochemistry.Conclusion Th17 may play certain role in the pathogenesis of EAU. |
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| Keywords: | IL-17 |
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