| 咳喘宁对病毒诱发哮喘患儿Th亚群的调节作用 |
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| 引用本文： | 王孟清,罗银河,陈锡军,朱晔,刘克丽,莫非钧,舒兰.咳喘宁对病毒诱发哮喘患儿Th亚群的调节作用[J].中华中医药杂志,2007,22(7):481-483. |
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| 作者姓名： | 王孟清 罗银河 陈锡军 朱晔 刘克丽 莫非钧 舒兰 |
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| 作者单位： | 湖南中医药大学第一附属医院,长沙,410007 |
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| 摘 要： | 目的：观察咳喘宁对病毒诱发哮喘患儿Th亚群细胞因子表达的影响。方法：120例病毒诱发哮喘患儿随机分为咳喘宁治疗级组60例和西药对照组60例，分别采用咳喘宁、利巴韦林治疗，观察两组患儿治疗后血清中IL-12、IL-4的含量变化。结果：咳喘宁能显著提高患儿血中IL-12，降低IL-4，其作用明显优于对照组。结论：咳喘宁治疗病毒诱发小儿哮喘的机制可能与提高患儿IL-12水平、降低IL-4水平有关。
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| 关 键 词： | 哮喘 咳喘宁 白细胞介素-4 白细胞介素-12 |
| 修稿时间： | 2006-10-28 |
Effect of Kechuanning on Adjusting Cytokine in Children with Virus-induced Asthma |
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| Wang Mengqing,Luo Yinghe,Chen Xijun,Zhu Ye,Liu Keli,Mo Feijun,Shu Lan.Effect of Kechuanning on Adjusting Cytokine in Children with Virus-induced Asthma[J].China Journal of Traditional Chinese Medicine and Pharmacy,2007,22(7):481-483. |
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| Authors: | Wang Mengqing Luo Yinghe Chen Xijun Zhu Ye Liu Keli Mo Feijun Shu Lan |
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| Institution: | First Affiliated Hospital, Hunan University of TCM, Changsha 410007 |
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| Abstract: | Objective:To observe the effect of Kechuanning on Th cytokine expression in pediatric virus-induced asthma.Methods:120 cases of pediatric virus-induced asthma were randomly divided into Kechuanning group(treatment group,n =60,treated with Kechuanning) and Western medicine group(control group,n=60,treated with virazole).The change of Th1 cytokine IL-12 and Th2 cytokine IL-4 in blood serum were detected and analyzed.Results:Kechuanning could increase IL-12 but decrease IL-4 level in the patient's blood,therefore regulate Th cell subset,and the effect was more obvious than in control group.Conclusion:The mechanism of Kechuanning in curing pediatrics asthma induced by virus was related with increasing IL-12 and decreasing IL-4 level. |
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| Keywords: | asthma Kechuanning IL-4(Interleukin-4) IL-12 |
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