Automated Neuropsychological Test Battery (CANTAB) in mild cognitive impairment and in Alzheimer's disease |
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Authors: | Egerházi Anikó Berecz Roland Bartók Eniko Degrell István |
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Affiliation: | Department of Psychiatry, University of Debrecen Medical and Health Science Center, 98, Nagyerdei krt., H-4012 Debrecen, Hungary. egerhazi@dote.hu |
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Abstract: | Neuropsychological deficits, such as poor episodic memory, are consistent features of mild cognitive impairment and also that of early stage of dementia. The aim of the present study was to detect cognitive dysfunction among patients with Alzheimer's disease or with mild cognitive impairment (MCI), which refers to a transitional state between the cognition of normal aeging and mild dementia regarded as a high-risk condition for the development of clinically probable Alzheimer's disease (AD). Computerized tests of memory, attention and executive functions were studied in groups of AD subjects (n=15) and MCI subjects (n=25). On all measures, the performance of the AD group was significantly weaker compared to healthy individuals or to the MCI group. The performance of both the AD and MCI patients in the Paired Associate Learning test was significantly impaired, which may suggest that MCI patients are already in the early stages of the disease. |
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Keywords: | AD, Alzheimer's Disease CANTAB, Cambridge Neuropsychological Automated Test Battery CDR, Clinical Dementia Rating CT, Computed Tomography DSM, Diagnostic Statistical Manual of Mental Disorders ICD, International Classification of Diseases MCI, Mild Cognitive Impairment MMSE, Mini Mental State Examination MRI, Magnetic Resonance Imaging NINCDS-ADRDA, National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association—Criteria for clinical diagnosis of Alzheimer's disease PAL, Paired Associate Learning VD, Vascular Dementia. |
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