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Automated Neuropsychological Test Battery (CANTAB) in mild cognitive impairment and in Alzheimer's disease
Authors:Egerházi Anikó  Berecz Roland  Bartók Eniko  Degrell István
Institution:Department of Psychiatry, University of Debrecen Medical and Health Science Center, 98, Nagyerdei krt., H-4012 Debrecen, Hungary. egerhazi@dote.hu
Abstract:Neuropsychological deficits, such as poor episodic memory, are consistent features of mild cognitive impairment and also that of early stage of dementia. The aim of the present study was to detect cognitive dysfunction among patients with Alzheimer's disease or with mild cognitive impairment (MCI), which refers to a transitional state between the cognition of normal aeging and mild dementia regarded as a high-risk condition for the development of clinically probable Alzheimer's disease (AD). Computerized tests of memory, attention and executive functions were studied in groups of AD subjects (n=15) and MCI subjects (n=25). On all measures, the performance of the AD group was significantly weaker compared to healthy individuals or to the MCI group. The performance of both the AD and MCI patients in the Paired Associate Learning test was significantly impaired, which may suggest that MCI patients are already in the early stages of the disease.
Keywords:AD  Alzheimer's Disease  CANTAB  Cambridge Neuropsychological Automated Test Battery  CDR  Clinical Dementia Rating  CT  Computed Tomography  DSM  Diagnostic Statistical Manual of Mental Disorders  ICD  International Classification of Diseases  MCI  Mild Cognitive Impairment  MMSE  Mini Mental State Examination  MRI  Magnetic Resonance Imaging  NINCDS-ADRDA  National Institute of Neurological and Communicative Disorders and Stroke/Alzheimer's Disease and Related Disorders Association—Criteria for clinical diagnosis of Alzheimer's disease  PAL  Paired Associate Learning  VD  Vascular Dementia  
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