百令胶囊对Graves 病自身抗体的影响

目的:观察百令胶囊对Graves病(Graves’disease,GD)患者甲状腺自身抗体及远期预后的影响。方法:将60例初诊断Graves病患者随机分为两组,治疗组用百令胶囊(2 g/次,每日3次)联合丙塞磷氧嘧啶50～600 mg治疗,对照组丙塞磷氧嘧啶50～600 mg治疗,连续用药12个月,观察两组治疗前后甲状腺功能、自身抗体变化,停药后随访1年,观察GD复发率。结果:治疗结束时两组甲状腺功能差异不显著,治疗组甲状腺自身抗体TRAb(9.28±3.59)U.mL-1,TPOAb(18.64±7.17)U.mL-1]较对照组(19.57±9.25,31.36±11.53)U.mL-1降低,差异有显著性意义(P<0.01);停药1年后随访,治疗组18.8%较对照组35.7%复发率明显降低,差异有显著性意义(P<0.05)。结论:百令胶囊可以降低GD患者自身抗体水平,对GD患者的异常免疫反应有一定的调节作用。

Effect of Bailing Capsule on Thyroid Auto Antibodies in Patients with Graves' Disease

Objective: To observe the effect of Bailing capsule on thyroid auto antibodies in patients with Graves' disease(GD). Method: Sixty first diagnosed cases of GD patients were randomly divided into two groups, control group treated with propylthiouracil and treatment group treated with Bailing capsule combined with propylthiouracil. The levels of FT₃,FT₄,sTSH,TRAb,TPOAb were measured in two group pre and post treatment. Follow-up 1 year after treatment,observe the recurrence rate of GD. Result: The thyroid function of the two groups was not significant after treatment, in the treatment group thyroid autoantibodies (TRAb, TPOAb) lower than the control group, the difference was significant (P <0.01); follow-up 1 year after withdrawal, the treatment group than the control group recurrence rate was significantly lower, the difference was significant (P<0.05). Conclusion: Bailing capsule can reduce autoantibody levels in patients with GD, and have some regulatory role to the abnormal immune response in patients with GD.