锌对甲基汞染毒大鼠肝、脑金属硫蛋白含量和超微结构的影响

目的 观察锌对甲基汞染毒大鼠肝、脑中金属硫蛋白含量和细胞超微结构的影响.方法 将大鼠随机分为硫酸锌＋甲基汞实验组、甲基汞染毒组和空白组,取大鼠部分肝、脑分别测定金属硫蛋白（MT）含量,并做细胞超微结构观察.结果 锌能增强甲基汞染毒大鼠肝、脑中金属硫蛋白含量;超微结构观察甲基汞实验组肝、脑细胞出现细胞间隙增宽,细胞质中线粒体致密、核糖体增多、内质网肿胀、有空泡化、染色质聚集等现象,而硫酸锌＋甲基汞实验组肝、脑细胞与对照组相比无明显差异.结论 锌能有效抑制甲基汞对细胞造成的损伤.

The Effect of Zinc on Content of Metallothionein and Ultrastructure in Liver and Brain of Rats Injected with Methylmercury

Objective To study the effect of zinc on metallothionein content and cell ultrastructural in liver and brain of rats treated with methylmercury. Methods The rats were randomly divided into four groups： zinc sulfate group, Zn sulfate＋MeHg group, MeHg group and control group. The metallothionein （MT） contents and cell ultrastructure in liver and brain were examed. Results Zinc can enhance metallothionein content in the liver and brain of rats exposed to methylmercury. The result of live and brain cells ultrastructure of rats exposed to methylmercury also reveal that cell gap widened, dense mitochondria in the cytoplasm, ribosome increased, accompanied by swelling of the endoplasmic reticulum vacuolization, chromatin aggregation. In contrast, compared with the control group, the zinc sulfate ＋ methylmercury group is no significant difference. Condusion Zinc can inhibit the cell damage caused by methylmercury.