| 人参二醇组皂苷对内毒素休克大鼠体内血管活性物质的调节作用 |
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| 引用本文： | 于蕾,王健春,黄民,孙晓霞.人参二醇组皂苷对内毒素休克大鼠体内血管活性物质的调节作用[J].中国老年学杂志,2011,31(15). |
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| 作者姓名： | 于蕾 王健春 黄民 孙晓霞 |
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| 作者单位： | 1. 吉林大学白求恩医学院生理学系,吉林,长春,130021
2. 吉林大学白求恩医学院机能科学实验中心 |
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| 摘 要： | 目的 探讨人参二醇组皂苷(PDS)对内毒素休克大鼠体内血管活性物质的调节作用.方法 大鼠舌下静脉注射PDS进行预治疗,10 min后注射细菌内毒素(LPS,5 mg/kg)复制感染性休克模型.实验动物随机分为对照组(C组),内毒素休克组(L组),地塞米松预治疗组(LD组),PDS预治疗组(LP组).各组大鼠于休克2、4 h腹主动脉取血,硝酸还原酶法测定血清中一氧化氮合酶(NOS) 活性和NO-2/NO-3的变化,间接反映NO的水平.于休克后4 h处死动物,称取肝组织20 mg匀浆后测血栓素B2(TXB2)及6-酮-前列腺素F1α(6-Keto-PGF1α)的含量.结果 肝组织中TXB2、6-keto-PGF1α及6-Keto-PGF1α/TXB2在LP组均显著低于L组.注射内毒素2 h后L组的血清NOS和NO-2/NO-3明显升高,LD组和LP组NOS活性、NO-2/NO-3显著低于L组.结论 PDS能够降低内毒素休克大鼠TXA2、PGI2和NO的水平,改善微循环状态,起到抗休克的作用.
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| 关 键 词： | 人参二醇组皂苷 血栓素B2 6-酮-前列腺素F1α 一氧化氮 |
Effects of PDS on vasoactive substances of endotoxin shock rats |
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| YU Lei,WANG Jian-Chun,HUANG Min,et al..Effects of PDS on vasoactive substances of endotoxin shock rats[J].Chinese Journal of Gerontology,2011,31(15). |
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| Authors: | YU Lei WANG Jian-Chun HUANG Min |
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| Institution: | YU Lei,WANG Jian-Chun,HUANG Min,et al. Department of Physiology,School of Norman Bethune Medical Sciences,Jilin University,Changchun 130021,Jilin,China |
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| Abstract: | Objective To observe the effects of Ginsen panaxadiol saponins(PDS) on vasoactive substances of endotoxin shock rats.Methods Rats were given pre-treatments by sublingual venous injection of PDS and were injected lipopolysaccharide(LPS,5 mg/kg) 10 min later to generate the septic shock models.Experimental rats were randomly divided into LPS,LPS+dexamethasone(Dex),LPS+PDS(45,90 mg/kg) and control groups respectively.The shocked rats of different groups rats were drawn blood from abdominal aortas 2 and 4 h aft... |
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