桂郁金提取物的抗炎镇痛作用

目的:研究桂郁金提取物的镇痛抗炎作用。方法:选用昆明种小鼠,体重(22±2)g,每个实验随机分为6组,生理盐水组、阳性对照组、醇提物、水提物低、高剂量组(按生药量计8,16 g.kg-1)。各组小鼠分别连续ig 7 d,用小鼠醋酸致痛、热致痛、二甲苯致小鼠耳廓肿胀和冰醋酸致小鼠腹腔渗出及小鼠棉球肉芽肿模型,观察桂郁金提取物的抗炎镇痛作用。结果:桂郁金醇提物、水提物低、高剂量对小鼠痛阈有明显的提高作用,扭体反应抑制率分别为59%,67%,59%,76%(P<0.01);桂郁金醇提物大剂量对二甲苯致小鼠耳廓肿胀有抑制作用,肿胀抑制率49%(P<0.05);桂郁金醇提物、水提物对冰醋酸致小鼠腹腔毛细血管通透性增高、小鼠棉球肉芽肿增生均有抑制作用(P<0.01)。结论:桂郁金提取物有抗炎镇痛作用。

Anti-inflammatory and Analgesia Effects of Extract of Curcuma kwangsiensis

Objective: To investigate the analgesia and anti-inflammatory effects of the extract of Curcuma kwangsiensis S.G.Lee et C.F.Liang(CKG). Method: Kunming mice (22±2) g were divided into 6 groups randomly. Namely physiological saline group, masculine control group, the extract of CKG low dose (8 g·kg^-1) and the extract of CKG high dose (16 g·kg^-1) groups. The mice were orally given correspondence drug for 7 days in every group. The analgesia effect of CGK was observed by hot-plate procedure and writhing body method.The anti-inflammatory effects were observed by the pinna swelling model of mice, and the cotton ball granuloma model of mice. Result: The ethanol extract and water extract of CKG could increase pain threshold markedly(P<0.01),the inhibitory rate was 59%, 67%, 59%,76% accordingly. The ethanol extract of CKG high-dose group could inhibite auricle swelling caused by xylenes in mouse(P<0.05),the inhibitory rate was 49%. The ethanol extract and water extract of CKG produced obvious anti-inflammatory effects in other animal models of acute or chronic experimental inflammation(P<0.01). Conclusion: CKG has anti-inflammatory and analgesic effects.