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| 木质素次生代谢工程的研究概况和进展 | |
| 引用本文： | 胡永胜,肖莹,邸鹏,张磊,陈万生. 木质素次生代谢工程的研究概况和进展[J]. 药学实践杂志, 2011, 29(4): 256-259,271 |
| 作者姓名： | 胡永胜 肖莹 邸鹏 张磊 陈万生 |
| 作者单位： | 1. 第二军医大学长征医院药学部,上海20003;解放军第118医院药械科,浙江,温州,325000 2. 第二军医大学长征医院药学部,上海20003;第二军医大学现代中药研究中心,上海,200433 3. 第二军医大学生药学教研室,上海,200433 |
| 摘 要： | 目的介绍木质素次生代谢工程的研究概况和进展。方法通过查阅文献,对木质素结构、生源合成、系统生物学和调控新策略等方面的进展作一综述。结果和结论木质素是酚类多聚体,是维管植物细胞壁的重要组成成分。木质素单体的次生代谢途径已经被阐明,木质素单体的种类及比例可以被基因工程手段调控。 |
| 关 键 词： | 木质素 生源合成 次生代谢工程 |
| 收稿时间： | 2010-06-07 |
| 修稿时间： | 2010-12-14 |
Advances of metabolic engineering in lignin biosynthesis |
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| HU Yong-sheng,XIAO Ying,DI Peng,ZHANG Lei and CHEN Wan-sheng. Advances of metabolic engineering in lignin biosynthesis[J]. The Journal of Pharmaceutical Practice, 2011, 29(4): 256-259,271 | |
| Authors: | HU Yong-sheng XIAO Ying DI Peng ZHANG Lei CHEN Wan-sheng |
| Affiliation: | Department of Pharmacy,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China;Department of Pharmacy, The 118th Hospital of PLA,Wenzhou 325000,China;Department of Pharmacy,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China;Modern Research Center for Traditional Chinese Medicine, Second Military Medical University, Shanghai 200433,China;Department of Pharmacy,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China;Modern Research Center for Traditional Chinese Medicine, Second Military Medical University, Shanghai 200433,China;Department of Pharmacognosy,School of Pharmacy,Second Military Medical University,Shanghai 200433,China;Department of Pharmacy,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China;Modern Research Center for Traditional Chinese Medicine, Second Military Medical University, Shanghai 200433,China |
| Abstract: | Objective To introduce advances of metabolic engineering in lignin biosynthesis. Methods The structure of lignin, biosynthesis, systems biology and new metabolic engineering strategies were reviewed. Results & Conclusions Lignin was a phenolic polymer, which was usually located in the secondary walls of plant cells. Secondary metabolic pathways of lignin monomers had been stated, and the types and proportions of lignin monomer could be regulated by metabolic engineering. |
| Keywords: | lignin biosynthesis secondary metabolic engineering |
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