咖啡因口香糖的制备及含量测定研究

目的研制一种新型含咖啡因的口香糖,并建立其含量测定的方法。方法建立咖啡因口香糖制备工艺,首先将咖啡因粉末与糖料均匀混合,与口香糖胶基调和,切割挤压,冷却老化,包装。建立咖啡因口香糖的含量测定方法,采用沸水浴加热1 h提取口香糖中的咖啡因,通过高效液相色谱法测定其中咖啡因的含量。结果制得的咖啡因口香糖含量均匀,口感较好;其含量测定方法线性良好,提取回收率为（98.41±2.02）%,方法学研究符合测定要求。结论咖啡因口香糖制备工艺简单,含量测定的质量可控,操作简便、快速、准确。

Studies on preparation and content determination of caffeine chewing gum (1. ;2. ) [Abstract] [Key words]

Objective To develop a new type of chewing gum contained caffeine, and a method for determination of caffeine in the chewing gum. Methods the caffeine powder and sugar powder were mixed evenly. the mixtures were reconciled with the chewing gum which were then cutted, extruded ,cooled and packaged. The caffeine in the gum was extracted by boiling water bath for 1h and caffeine content was determind by HPLC. Results This type of gum tastd good and the caffeine contained in the gum was uniform; The calibration curve showed good linearity in the range, and the mean of the extraction recovery rate was 98.41 ± 2.02%. Methodology of this study met the requirements of determination. Conclusion The technology of caffeine gum was simple and available; the developed HPLC method was easy, rapid , accurate and the quality was under control.