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| 浙贝止咳颗粒镇咳祛痰及抗菌作用研究 | |
| 引用本文： | 王海青,阚红卫,靳康,石静丽,梁燕,田军,杨士友. 浙贝止咳颗粒镇咳祛痰及抗菌作用研究[J]. 中国实验方剂学杂志, 2011, 17(16): 207-210 |
| 作者姓名： | 王海青 阚红卫 靳康 石静丽 梁燕 田军 杨士友 |
| 作者单位： | 1. 安徽大学生命科学学院,合肥,230023;安徽省药物研究所药理室,安徽省药品临床前安全评价中心,安徽省中药研究与开发重点实验室,合肥,230022 2. 安徽省药物研究所药理室,安徽省药品临床前安全评价中心,安徽省中药研究与开发重点实验室,合肥,230022 3. 安徽省药物研究所中药二室,合肥,230022 |
| 摘 要： | 目的:观察浙贝止咳颗粒的镇咳、祛痰、抗菌等相关药效学作用。方法:将小鼠随机分为NS、阳性药和浙贝止咳颗粒高、中、低剂量组(24.4,12.2,6.1 g.kg-1),ig 6 d,采用小鼠氨水引咳实验观察其镇咳作用,小鼠酚红排泌实验观察其祛痰作用;将大鼠随机分为NS、阳性药和浙贝止咳颗粒高、中、低剂量组(18.4,9.2,4.6 g.kg-1),ig 6 d,采用毛细管排痰实验观察其祛痰作用;体内外抗菌实验观察其对相关细菌的抗菌作用及对细菌感染的小鼠死亡保护作用。结果:浙贝止咳颗粒高、中剂量可延长氨水所致小鼠咳嗽的潜伏期,减少咳嗽次数(P<0.01);增加小鼠离体气管酚红排泌量及大鼠毛细管排痰量(P<0.05或P<0.01);对金黄色葡萄球菌(抑菌圈直径14 mm,MIC 3.9 g.L-1,MBC 7.8 g.L-1)和肺炎链球菌(抑菌圈直径16 mm,MIC 15.6 g.L-1,MBC 31.2 g.L-1)有较强的体外抗菌作用,对金黄色葡萄球菌和肺炎链球菌引起小鼠死亡有一定的保护作用(P<0.01)。结论:浙贝止咳颗粒具有明显的镇咳、祛痰、抗菌作用。 |
| 关 键 词： | 浙贝止咳颗粒 镇咳 祛痰 抗菌 |
| 收稿时间： | 2011-01-21 |
Antitussive, Expectorant and Antibacterial Actions of Zhebei Zhike Granules |
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| WANG Hai-qing,KAN Hong-wei,JIN Kang,SHI Jing-li,LIANG Yan,TIAN Jun and YANG Shi-you. Antitussive, Expectorant and Antibacterial Actions of Zhebei Zhike Granules[J]. China Journal of Experimental Traditional Medical Formulae, 2011, 17(16): 207-210 | |
| Authors: | WANG Hai-qing KAN Hong-wei JIN Kang SHI Jing-li LIANG Yan TIAN Jun YANG Shi-you |
| Affiliation: | Anhui University School of Life Science, Heifei 230023, China;Pharmacological Department, Anhui Institute of Material Medica, Anhui Provincial Center for Drug Safety Pre-clinical Evaluation, The Key Lab of Chinese Traditional Medicine Research and Development, Heifei 230022, China;Pharmacological Department, Anhui Institute of Material Medica, Anhui Provincial Center for Drug Safety Pre-clinical Evaluation, The Key Lab of Chinese Traditional Medicine Research and Development, Heifei 230022, China;Anhui University School of Life Science, Heifei 230023, China;Pharmacological Department, Anhui Institute of Material Medica, Anhui Provincial Center for Drug Safety Pre-clinical Evaluation, The Key Lab of Chinese Traditional Medicine Research and Development, Heifei 230022, China;Pharmacological Department, Anhui Institute of Material Medica, Anhui Provincial Center for Drug Safety Pre-clinical Evaluation, The Key Lab of Chinese Traditional Medicine Research and Development, Heifei 230022, China;Pharmacological Department, Anhui Institute of Material Medica, Anhui Provincial Center for Drug Safety Pre-clinical Evaluation, The Key Lab of Chinese Traditional Medicine Research and Development, Heifei 230022, China;Traditional Chinese Medicine Department, Anhui Institute of Material Medica, Heifei 230022, China;Pharmacological Department, Anhui Institute of Material Medica, Anhui Provincial Center for Drug Safety Pre-clinical Evaluation, The Key Lab of Chinese Traditional Medicine Research and Development, Heifei 230022, China |
| Abstract: | Objective: To study the antitussive, expectorant and antibacterial effects of Zhebei Zhike granules. Method: Mice were divided into 5 groups randomly: Normal saline (NS) group, positive group, high dose group, middle dose group and low dose group of Zhebei Zhike granules (24.4,12.2,6.1 g·kg-1), after 6 d by ig administration, the antitussive effect was studied by the cough model induced by ammonia in mice, the expectorant effect was studied by a mouse model of phenol red test. Rats were divided into 5 groups randomly: NS group, positive group, high dose group, middle dose group and low dose group of Zhebei Zhike granules (18.4,9.2,4.6 g·kg-1), after 6 d by ig administration, the expectorant effect was studied by testing the amount of phlegm secreted in rats. Experimental research on antibacterial action of Zhebei Zhike granules was applied to observe the antibacterial effect. Result: The experimental results showed that high dose group and middle dose group of Zhebei Zhike granules could produce a protective effect on the cough induced by ammonia (P<0.01), increase phenol red excretion in mice and phlegm expelling in rats (P<0.05 or P<0.01). The granules showed obvious antibacterial actions against Staphylococcus aureus (the diameter of inhibition zone is 14mm,MIC is 3.9 mg·mL-1,MBC is 7.8 mg·mL-1) and Streptococcus pneumonia (the diameter of inhibition zone is 16mm,MIC is 15.6 mg·mL-1,MBC is 31.2 mg·mL-1),and also showed some protective effect to mice infected with bacteria (P<0.01). Conclusion: Zhebei Zhike granules have obvious antitussive, expectorant and antibacterial actions. |
| Keywords: | Zhebei Zhike granules antitussive action expectorant action antibacterial action |
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