去羟肌苷散、司他夫定和奈韦拉平联合治疗艾滋病患者6个月疗效观察

目的观察去羟肌苷散、司他夫定和奈韦拉平3药联合治疗艾滋病患者6个月时的疗效及不良反应。方法艾滋病患者8例，给予去羟肌苷散、司他夫定和奈韦拉平3药联合治疗，随访6个月。监测患者治疗前、治疗1个月、治疗3个月、治疗6个月时的血浆病毒载量及CD4^ T淋巴细胞计数，并评价药物不良反应。结果经过6个月治疗患者血浆中HIV RNA含量明显降低，CD4^ T淋巴细胞数量增加，药物不良反应轻微。结论去羟肌苷散、司他夫定和奈韦拉平3药联合治疗能有效抑制艾滋病病毒的复制，机体免疫功能亦有改善，并具有良好的耐受性。

The first 6-months evaluation on the efficacy of combined therapv with didanosine, stavudine and nevirapine in AIDS patients

Objective To observe the efficacy and side ef fe cts of combined therapy with didanosine,stavudine and nevirapine in AIDS patient s.Methods Eight patients with AIDS were treated by combination of didanosine,stavudine and nevirapine.All cases were followed up for 6 months.The plasma HIV-1 RNA level and CD 4 T cell counts of the patients were measured a t the beginning of treatment and the end of the first,third and sixth month.Adve rse events were monitored in all of 8 patients.Results The level of plasma HIV-1 RNA was significantly decrea sed( P <0.001),and CD 4 cell counts were significantly increased( P =0.014) in all patients.The adverse effects of the three kinds of drugs were mild durin g the first 6-months.Conclusions During the first 6-months,8 patients who received combined therapy of didanosine,stavudine and nevirapine were well tolerated,and got rapid immunological and antiviral response.