| 年龄相关性黄斑变性的病因研究 |
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| 引用本文： | 李娟,胡永华. 年龄相关性黄斑变性的病因研究[J]. 国际眼科杂志, 2008, 8(10): 2102-2105 |
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| 作者姓名： | 李娟 胡永华 |
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| 作者单位： | 北京大学医学部公共卫生学院流行病与卫生统计学系,教育部流行病学重点实验室,中国北京市,100191;北京大学医学部公共卫生学院流行病与卫生统计学系,教育部流行病学重点实验室,中国北京市,100191 |
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| 基金项目： | 中国“十一五”国家科技支撑计划“老年相关疾病的干预控制研究”重点项目(No.2006BAI02B05)~~ |
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| 摘 要： | 年龄相关性黄斑变性(age-related macular degeneration,AMD)是发达国家老年人致盲的主要原因,在我国其发病率也呈上升趋势。它是一种由环境和遗传共同作用所导致的复杂性疾病。患病率随年龄的增加而增加。吸烟是明确的危险因素。应用基因组连锁扫描和关联分析,已经发现多个潜在的致病基因。补体因子H与AMD的关系提示替代补体途径在AMD发生发展过程中的重要作用。PLEKHA1/LOC387715/HTRA1基因位点的变异也是AMD发病的主要危险因素。理解环境和遗传因素之间的交互作用将有利于AMD预防措施和治疗手段的探索。本文对目前AMD的流行病学,发病机制和病因学的进展进行综述。
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| 关 键 词： | 年龄相关性黄斑变性 发病机制 遗传易感性 危险因素 |
Recent advance of the study on age-related macular degeneration |
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| Juan Li,Yong-Hua Hu. Recent advance of the study on age-related macular degeneration[J]. International Eye Science, 2008, 8(10): 2102-2105 |
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| Authors: | Juan Li Yong-Hua Hu |
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| Affiliation: | Department of Epidemiology and Biostatistics,Peking University Health Science Center,and Key Laboratory of Epidemiology of Peking University,Ministry of Education,Beijing 100191,China |
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| Abstract: | Age-related macular degeneration(AMD)is the leading cause of blindness in industrialized countries and the incidence is rising in China.AMD is a complex disease caused by the combination of environmental factors and genetic predisposition.The prevalence of AMD increases with age.The adverse effect of smoking is well established.Using genome linkage scan and association studies,multiple potentially causative genes have been identified.The association of complement factor H with AMD highlights the importance ... |
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| Keywords: | age-related macular degeneration pathogenesis genetic predisposition environmental risk |
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