| PTEN蛋白和CyclinD1在垂体瘤中的表达和相关性研究 |
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| 引用本文： | 高建国,范月超,张华秋,舒凯,雷霆.PTEN蛋白和CyclinD1在垂体瘤中的表达和相关性研究[J].中国肿瘤临床,2005,32(11):601-603. |
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| 作者姓名： | 高建国 范月超 张华秋 舒凯 雷霆 |
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| 作者单位： | 华中科技大学同济医学院附属同济医院神经外科,武汉市,430030 |
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| 基金项目： | 国家自然科学基金资助(编号:39670736) |
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| 摘 要： | 目的:探讨垂体瘤中抑癌基因PTEN和CyclinD1表达的临床意义。方法:应用免疫组织化学技术检测56例垂体肿瘤,5例正常垂体组织中PTEN和CyclinD1蛋白的表达情况。结果:5例正常垂体组织和22例非侵袭垂体瘤中PTEN表达阳性率和强阳性率比34例侵袭性垂体瘤中PTEN的强阳性率和阳性率强度明显增加,有显著性差异(P<0.01)。正常垂体组织和非侵袭性垂体瘤细胞内CyclinD1蛋白表达较弱,甚至不表达,侵袭性垂体瘤细胞内CyclinD1的表达率和强度明显增加(P<0.01),并且发现在PTEN蛋白表达显著减少的病例中伴随CyclinD1蛋白表达增加,经过相关性分析发现两者呈显著性相关关系(P<0.05)。结论:抑癌基因PTEN的失活和CyclinD1蛋白表达增加与垂体瘤的侵袭性有一定的相关性。
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| 关 键 词： | 垂体瘤PTEN CyclinD1侵袭性 |
| 文章编号： | 1000-8179(2005)11-0601-03 |
The Research on Expression of PTEN Protein and CyclinD1 in Pituitary Tumor and Its Significance |
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| Gao Jianguo Fan Yuechao Zhang Huaqiu et al.The Research on Expression of PTEN Protein and CyclinD1 in Pituitary Tumor and Its Significance[J].Chinese Journal of Clinical Oncology,2005,32(11):601-603. |
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| Authors: | Gao Jianguo Fan Yuechao Zhang Huaqiu |
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| Institution: | Gao Jianguo Fan Yuechao Zhang Huaqiu et al Department of Neurosurgery,Tongji Hospital of Tongji Medical College,Huazhong University of Science and Technology,Wuhan |
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| Abstract: | Objective: To explore the significance of PTEN and CyclinD1 expression in human pituitary adenomas. Methods: Immunohistochemistry was applied to examine the expression of PTEN and CyclinD1 in 56 specimens of pituitary adenomas and 5 specimens of normal pituitary. Results: The expression of PTEN in invasive pituitary adenomas was significantly different, compared to non- invasive pituitary adenomas. The expression of CyclinD1 in invasive pituitary adenomas was significantly different from that in non-invasive pituitary adenomas. Conclusion: The change in the expression of PTEN CyclinD1 protein is related to the invasiveness of pituitary adenomas. |
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| Keywords: | Pituitary adenomas PTEN CyclinD1 Prognosis |
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