Effects of Danshen tablets on pharmacokinetics of atorvastatin calcium in rats and its potential mechanism |
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| Authors: | Sen Sun Rong Wang Jie Fan |
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| Affiliation: | 1. Department of Pharmacy, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, China;2. Department of Pharmacy, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China;3. Department of Pharmacy, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China |
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| Abstract: | Context: Danshen tablets (DST), an effective traditional Chinese multi-herbal formula, are often combined with atorvastatin calcium (AC) for treating coronary heart disease in the clinic.Objective: This study investigated the effects of DST on the pharmacokinetics of AC and the potential mechanism.Materials and methods: The pharmacokinetics of AC (1?mg/kg) with or without pretreatment of DST (100?mg/kg) were investigated using LC-MS/MS. The effects of DST (50?μg/mL) on the metabolic stability of AC were also investigated using rat liver microsome incubation systems.Results: The results indicated that Cmax (23.87?±?4.27 vs. 38.94?±?5.32?ng/mL), AUC(0–t) (41.01?±?11.32 vs. 77.28?±?12.92?ng h/mL), and t1/2 (1.91?±?0.18 vs. 2.74?±?0.23?h) decreased significantly (p?t1/2) of AC was also decreased (25.7?±?5.2 vs. 42.5?±?6.1) with the pretreatment of DST.Discussion and conclusions: This study indicated that the main components in DST could accelerate the metabolism of AC in rat liver microsomes and change the pharmacokinetic behaviors of AC. So these results showed that the herb-drug interaction between DST and AC might occur when they were co-administered. Therefore, the clinical dose of AC should be adjusted when DST and AC are co-administered. |
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| Keywords: | Herb-drug interaction LC-MS/MS metabolism |
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